ANTI-Puma BH3 Domain Antibody

货号： AB10418      产品名称： ANTI-Puma BH3 Domain Antibody   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-Puma BH3 domain Antibody
Species Reactivity Key Applications Host Format Antibody Type
M  WB Rabbit Purified Polyclonal Antibody
Description:
Anti-Puma BH3 domain Antibody
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Specificity:
The antibody reacts with the 21 kDa Puma BH3 domain protein.
Molecular Weight:
21 kDa
Immunogen:
This antibody was developed against a synthetic peptide selected from the C-terminal region of human Puma.
Background Information:
PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis
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Species Reactivity:
Mouse
Species Reactivity Note:
Reacts with mouse. Other species have not been tested.
Control:
Western Blot : Mouse brain lysate
Quality Assurance:
Western Blot Analysis: 1:250 dilution of this antibody detected Puma BH3 domain on mouse brain lysate.
Purification Method:
Protein G purfied
Presentation:
Purified in PBS with 0.09% NaN3.
Storage Conditions:
Store at 2-8°C for 6 months from date of receipt. For long term storage, store at -20°C
UniProt Number:
Q9BXH1
Entrez Gene Number:
NP_055232
Gene Symbol:
JFY-1
JFY1
PUMA
Alternate Names:
BCL2 binding component 3
Bcl-2 binding component 3
p53 up-regulated modulator of apoptosis
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
UniProt Summary:
FUNCTION: Essential mediator of p53-dependent and p53-independent apoptosis.
SUBUNIT STRUCTURE: Interacts with MCL1 and BCL2A1 By similarity. Interacts with BCL2 and BCL2L1/BCL-XL.
SUBCELLULAR LOCATION: Mitochondrion. Note= Localized to the mitochondria in order to induce cytochrome c release.
TISSUE SPECIFICTY: Ubiquitously expressed.
INDUCTION: By DNA damage, glucocorticoid treatment, growth factor deprivation and p53.
SEQUENCE SIMILARITIES: Belongs to the Bcl-2 family.
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Product Name:
Anti-Puma BH3 domain Antibody
Concentration:
Please refer to the Certificate of Analysis for the lot-specific concentration.
Antibody Type:
Polyclonal Antibody
Qty/Pk:
100 μg
Format:
Purified
Host:
Rabbit
Applications:
Anti-Puma BH3 domain Antibody is an antibody against Puma BH3 domain for use in WB.

2-8℃