标签： lkb

05-832   ANTI-LKB1, CLONE 5C10 100UG   品牌 Millipore

ANTI-LKB1, CLONE 5C10 100UG

货号： 05-832      产品名称： ANTI-LKB1, CLONE 5C10 100UG   品牌： Millipore 规格： EA 3周到货 生化实验

Anti-LKB1 Antibody, clone 5c10
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REFERENCES
Molecular diagnosis and clinical relevance of t(9;22), t(4;11) and t(1 ;19) chromosome abnormalities in a consecutive group of 141 adult patients with acute lymphoblastic leukemia
Rambaldi, A., et al (1996) Leuk Lymphoma, 21:457-66 (1996)
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.
Baas, A F, et al. (2003) EMBO J., 22: 3062-72 (2003)
Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD
Baas, A. F., et al (2004) Cell, 116:457-66 (2004)
Species Reactivity Key Applications Host Format Antibody Type
H, M, R  ICC, WB Mouse Purified Monoclonal Antibody
Description:
Anti-LKB1 Antibody, clone 5c10
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Specificity:
Recognizes LKB1.
Molecular Weight:
55 kDa
Immunogen:
GST fusion protein corresponding to residues 1-433 of human LKB1
Clone:
5c10
Isotype:
IgG
Species Reactivity:
Human
Mouse
Rat
Control:
Rat2 cell lysate
Quality Assurance:
routinely evaluated by immunoblot on RIPA lysates from Rat2 cells
Purification Method:
Protein G purfied
Presentation:
Protein G Purified immunoglobulin in 0.1M Tris-Glycine, 0.15M NaCl and 0.05% Sodium Azide, pH 7.4.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
Q15831
Entrez Gene Number:
NM_000455
Gene Symbol:
STK11
PJS
LKB1
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Entrez Gene Summary:
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
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Key Applications:
Immunocytochemistry
Western Blotting
UniProt Summary:
FUNCTION: SwissProt: Q15831 # Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.
COFACTOR: Magnesium or Manganese.
SIZE: 433 amino acids; 48636 Da
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2.
TISSUE SPECIFICITY: Ubiquitously expressed. Strongest expression in testis and fetal liver.
PTM: Phosphorylated by a cAMP-dependent protein kinase (By similarity).
DISEASE: SwissProt: Q15831 # Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) [MIM:175200]. PJS is a rare hereditary disease in which there is predisposition to benign and malignant tumors of many organ systems. PJS is an autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer. & Defects in STK11 have been associated with testic 2°C – 8°C

07-694   Anti-LKB1   品牌 Millipore

Anti-LKB1

货号： 07-694      产品名称： Anti-LKB1   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-LKB1 Antibody
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REFERENCES
Characterization of the liver kinase B1-mouse protein-25 -Ste-20-related adaptor protein complex in adult mouse skeletal muscle.
Cody D Smith,Richard A Compton,Joshua S Bowler,Jonathan T Kemp,Sterling N Sudweeks,David M Thomson,William W Winder (2011) Journal of applied physiology (Bethesda, Md. : 1985).111
Effect of LKB1 deficiency on mitochondrial content, fibre type and muscle performance in the mouse diaphragm.
J D Brown,C R Hancock,A D Mongillo,J Benjamin Barton,R A DiGiovanni,A C Parcell,W W Winder,D M Thomson (2011) Acta physiologica (Oxford, England).201
Skeletal muscle dysfunction in muscle-specific LKB1 knockout mice.
Thomson DM, Hancock CR, Evanson BG, Kenney SG, Malan BB, Mongillo AD, Brown JD, Hepworth S, Fillmore N, Parcell AC, Kooyman DL, Winder WW (2010) J Appl Physiol.108:1775-85. Epub 2010 Apr 1.
Role of adenosine monophosphate-activated protein kinase in the control of energy homeostasis.
Foufelle, Fabienne and Ferré, Pascal (2005) Current opinion in clinical nutrition and metabolic care, 8: 355-60 (2005)
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Species Reactivity Key Applications Host Format Antibody Type
R  WB Rabbit Purified Polyclonal Antibody
Description:
Anti-LKB1 Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Specificity:
Recognizes LKB1.
Molecular Weight:
Mr 51 kDa
Immunogen:
KLH-conjugated, synthetic peptide corresponding to amino acids 359-373 (KIEDGIIYTQDFTVPG- K) of mouse LKB1 with N and C-terminal K residues added for conjugation purposes
Isotype:
IgG
Species Reactivity:
Rat
Species Reactivity Note:
Predicted to cross-react with mouse and human based on sequence homology
Control:
Rat2 cell lysate
Quality Assurance:
routinely evaluated by immunoblot on Rat2 cell lysates
Purification Method:
Protein A purfied
Presentation:
Protein A Purified rabbit IgG in a solution of 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.135M NaCl, and 0.035% sodium azide as a preservative.
Storage Conditions:
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
UniProt Number:
Q15831
Entrez Gene Number:
NM_000455.4
Gene Symbol:
STK11
LKB1
PJS
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Western Blotting
Entrez Gene Summary:
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
View All »
UniProt Summary:
FUNCTION: SwissProt: Q15831 # Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.
COFACTOR: Magnesium or Man -20℃

09-478   Anti-phospho-LKB1 (Ser307)   品牌 Millipore

Anti-phospho-LKB1 (Ser307)

货号： 09-478      产品名称： Anti-phospho-LKB1 (Ser307)   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-phospho-LKB1 (Ser307)
Species Reactivity Key Applications Host Format Antibody Type
H, M, R, B, Eq  WB, DB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-phospho-LKB1 (Ser307) Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Specificity:
This antibody recognizes LKB1 when phosphorylated at Ser307.
Molecular Weight:
~ 49 kDa
Epitope:
Phosphorylated Ser307
Immunogen:
KLH-conjugated linear peptide corresponding to amino acids including and surrounding phosphorylated Ser307 of human LKB1.
Modifications:
Phosphorylation
Background Information:
LKB1 is a serine-threonine protein kinase and member of the calcium calmodulin family. LKB1 acts as a tumor suppressor and plays an important role in the regulation of many cellular processes. It is expressed in all tissues including pancreatic, liver, testicular, cardiac, and skeletal muscle tissue. Mutations in LKB1 result from unregulated cell growth and tumor formation that are associated with Peutz-Jehgers syndrome.
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Species Reactivity:
Human
Mouse
Rat
Bovine
Horse
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Species Reactivity Note:
Demonstrated to react with human. Predicted to react with mouse, rat, bovine, and equine based on 100% sequence homology.
Application Notes:
Western Blot Analysis: A previous lot was used by an independent laboratory in WB. (Xie, Z., et al. (2009). Molecular and Cellular Biology. 29(13):3582-3596.)
Control:
Modified and non-modified peptides of phosphorylated and non-phosphorlyated LKB1 protein
Quality Assurance:
Evaluated by Dot Blot in modified and non-modified peptides of phosphorylated and non-phosphorlyated LKB1 protein.
Dot Blot Analysis: 1 µg/mL of this antibody detected LKB1 in modified and non-modified peptides of phosphorylated and non-phosphorlyated LKB1 protein.
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Purification Method:
Affinity Purfied
Presentation:
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
Q15831
Entrez Gene Number:
NP_000446
Gene Symbol:
STK11
LKB1
PJS
Alternate Names:
Renal carcinoma antigen NY-REN-19
Serine/threonine-protein kinase LKB1
polarization-related protein LKB1
serine/threonine kinase 11
serine/threonine kinase 11 (Peutz-Jeghers syndrome)
serine/threonine protein kinase 11
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Western Blotting
Dot Blot
Entrez Gene Summary:
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq].
View All »
UniProt Summary:
FUNCTION: Essenti 2-8℃

09-495   Anti-phospho-LKB1 (Ser431)   品牌 Millipore

Anti-phospho-LKB1 (Ser431)

货号： 09-495      产品名称： Anti-phospho-LKB1 (Ser431)   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-phospho LKB1 (Ser431)
Species Reactivity Key Applications Host Format Antibody Type
M, H, R, B, Eq  WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-phospho LKB1 (Ser431) Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Specificity:
This antibody recognizes LKB1 when phosphorylated at Ser431.
Molecular Weight:
~ 55 kDa observed
Epitope:
Phosphorylated Ser431
Immunogen:
KLH-conjugated linear peptide corresponding to human LKB1 when phosphorylated at Ser431.
Modifications:
Phosphorylation
Background Information:
LKB1 is a serine-threonine protein kinase and member of the calcium calmodulin family. LKB1 acts as a tumor suppressor and plays an important role in the regulation of many cellular processes. It is expressed in all tissues including pancreatic, liver, testicular, cardiac, and skeletal muscle tissue. Mutations in LKB1 result from unregulated cell growth and tumor formation that are associated with Peutz-Jehgers syndrome.
View All »
Species Reactivity:
Mouse
Human
Rat
Bovine
Horse
View All »
Species Reactivity Note:
Demonstrated to react with mouse. Predicted to react with human, rat, bovine, and equine based on 100% sequence homology.
Application Notes:
Western Blot (Snap i.d.®) Analysis: 0.5 µg/mL from a previous lot detected LKB1 on 10 µg of NIH/3T3 treated with forskolin lysate.
Control:
NIH/3T3 cell lysate
Quality Assurance:
Evaluated by Western Blot in NIH/3T3 cell lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected LKB1 on 10 µg of NIH/3T3 cell lysate.
Purification Method:
Affinity purified
Presentation:
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
Q9WTK7
Entrez Gene Number:
NP_035622
Gene Symbol:
STK11
LKB1
PJS
Alternate Names:
Renal carcinoma antigen NY-REN-19
Serine/threonine-protein kinase LKB1
polarization-related protein LKB1
serine/threonine kinase 11
erine/threonine kinase 11 (Peutz-Jeghers syndrome)
serine/threonine protein kinase 11
View All »
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Western Blotting
UniProt Summary:
FUNCTION: Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases By similarity. Tumor suppressor.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. UniProtKB Q15831
COFACTOR: Magnesium or Manganese (By similarity). UniProtKB Q15831
ENZYME REGULATION: Activated by binding of a complex consisting of CAB39 and STRAD or CAB39 and ALS2CR2 By similarity. UniProtKB Q15831
SUBUNIT STRUCTURE: Found in a ternary complex composed of SMAD4, STK11 and STK11IP. Interacts with SMAD4, STK11IP and WDR6 (By similarity).
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2.
DEVELOPMENTAL STAGE: Ubiquitously expressed 7-11 dpc. Present in nucleated embryonic 2-8℃

3950-100   LKB1 Antibody   品牌 Biovision

LKB1 Antibody

货号： 3950-100      产品名称： LKB1 Antibody   品牌： Biovision 规格： 100 μg 3周到货 生化实验

LKB1 Antibody
Product Overview
Antibody Target: LKB1
Alternative Name: Serine/threonine kinase 11, Serine/threonine protein kinase 11, Renal carcinoma antigen NY-REN-19, polarization-related protein LKB1
Host: Rabbit
Antibody Type: Polyclonal
Isotype: Rabbit IgG
Immunogen: Synthetic peptide surroundign amino acid 294 of mouse LKB1
Accession#: ACE73833.1
Gene ID: 20869
Appearance: Colorless liquid
Concentration: 0.5 mg/ml
Formulation: 100 µg (0.5 mg/ml) affinity purified rabbit anti-LKB1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal
Purification: Affinity purified
Species Reactivity: human, mouse, rat
Application: Western blot
Application & Usage: The antibody can be used for Western blotting (0.5–4 µg/ml).
Storage Temp.: -20 °C
Shipping: gel pack
Background Descriptions: 100 µg (0.5 mg/ml) affinity purified antibody. Reacts with human/mouse/rat. Tested in Western Blotting.
Handling: The antibody solution should be gently mixed before use.
Usage: For Research Use Only! Not to be used in humans.

-20°C

3950BP-50   LKB1 Blocking Peptide   品牌 Biovision

LKB1 Blocking Peptide

货号： 3950BP-50      产品名称： LKB1 Blocking Peptide   品牌： Biovision 规格： 50 μg 3周到货 生化实验

LKB1 Blocking Peptide
Product Name: LKB1 Blocking Peptide
Antibody Target: Synaptotagmin
Accession #: P21707
Gene ID: 25716
Appearance: Colorless liquid
Concentration: 0.5mg/ml
Formulation: 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.
Storage Temp.: -20°C
Shipping: Gel Pack
Application & Usage: The peptide is used for blocking the antibody activity of synaptotagmin (Cat. # 3177-100). It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.
Description: 50 ug blocking peptide for synaptotagmin polyclonal Antibody (Cat. # 3177-100).
Handling: The peptide solution should be gently mixed before use
USAGE: For Research Use Only! Not For Use in Humans.

-20°C