标签归档：lipase

ABD66   Anti-Adipose Triglyceride Lipase (PN   品牌 Millipore

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Anti-Adipose Triglyceride Lipase (PN

货号： ABD66      产品名称： Anti-Adipose Triglyceride Lipase (PN   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-Adipose Triglyceride Lipase (PNPLA2)
Species Reactivity Key Applications Host Format Antibody Type
H, M, R, B  WB, IH(P) Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-Adipose Triglyceride Lipase (PNPLA2) Antibody
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Specificity:
This antibody recognizes Adipose Triglyceride Lipase at the lumenal domain.
Molecular Weight:
~53kDa observed. Uniprot describes 2 isoforms produced by alternative splicing with molecular weights of 55 kDa and 19 kDa.
Epitope:
Lumenal domain
Immunogen:
KLH-conjugated linear peptide corresponding to the lumenal domain of human Adipose Triglyceride Lipase.
Background Information:
Adipose Triglyceride Lipase, also known as PNPLA2, is a member of the PNPLA family of proteins. It specifically hydrolyses triglycerides and may be involved in the degradation of adiposomes. This protein is expressed in adipose tissue, heart, skeletal muscle, and portions of the gastrointestinal tract. Adipose Triglyceride Lipase has acylglycerol transacylase activity and may act coordinately with LIPE/HLS within the lipolytic cascade. Mutations in Adipose Triglyceride Lipase have been associated with neutral lipid storage disease with myopathy.
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Species Reactivity:
Human
Mouse
Rat
Bovine
Species Reactivity Note:
Demonstrated to react with Human, Mouse, and Rat.
Predicted to react with Bovine based on 100% sequence homology.
Application Notes:
Immunohistochemistry Analysis: A 1:300 dilution from a representative lot detected Adipose Triglyceride Lipase in human colon, rat skeletal muscle, and rat retina tissues.
Control:
NIH/3T3 L1 adipocytes
Quality Assurance:
Evaluated by Western Blot in NIH/3T3 L1 adipocytes.
Western Blot Analysis: 1 µg/mL of this antibody detected Adipose Triglyceride Lipase on 10 µg of NIH/3T3 L1 adipocytes.
Purification Method:
Protein A purified
Presentation:
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
Q96AD5
Entrez Gene Number:
NP_065109
Gene Symbol:
PNPLA2
ATGL
Alternate Names:
Patatin-like phospholipase domain-containing protein 2
Adipose triglyceride lipase
Calcium-independent phospholipase A2
Desnutrin
IPLA2-zeta
Pigment epithelium-derived factor
TTS2.2
Transport-secretion protein 2
TTS2
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Immunohistochemistry (Paraffin)
Entrez Gene Summary:
This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy. [provided by RefSeq, Jul 2010].
UniProt Summary:
FUNCTION: Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in t 2-8℃

10212-500   Monoacylglycerol Lipase (FL) Polyclonal Antibody   品牌 Cayman

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Monoacylglycerol Lipase (FL) Polyclonal Antibody

货号： 10212-500      产品名称： Monoacylglycerol Lipase (FL) Polyclonal Antibody   品牌： Cayman 规格： 500 碌l 3周

Monoacylglycerol Lipase (FL) Polyclonal Antibody Cayman Chemical Item Number 10212 Description Antigen: purified recombinant human monoacylglycerol lipase · Host: rabbit · Application(s): ICC, IHC, and WB · Endocannabinoids, such as arachidonoyl ethanolamide (AEA) and 2-arachidonoyl glycerol (2-AG), function as short-range modulators of cell and synaptic activity. Monoacylglycerol lipase (MAGL) hydrolyzes 2-AG to terminate its biological actions and works consecutively with hormone-sensitive lipase to mobilize fatty acids from the triglyceride stores of adipocytes.1↗,2↗ MAGL has a molecular weight of ~33 kDa and exhibits a high degree of homology among human, murine, and rat at the amino acid level.1↗,2↗,3↗,4↗ The enzyme is expressed in a variety of tissues with most abundant expression in skeletal muscle and adipose tissue, suggesting a role of MAGL in monoglyceride hydrolysis in diverse tissues. Cayman’s MAGL polyclonal antibody can be used for western blot, immunocytochemistry, and immunohistochemistry (paraffin embedded sections) analysis for MAGL. Synonyms MGL,MAGL Formulation purified rabbit polyclonal IgG in 500 μl TBS, pH 7.4, containing 50% glycerol, 0.5 mg/mL BSA, and 0.02% sodium azide Stability 1 year Storage -20°C Shipping Wet ice in continental US; may vary elsewhere Specificity Human MAGL,Rat MAGL -20°C

10006371-500   Hormone Sensitive Lipase Polyclonal Antibody   品牌 Cayman

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Hormone Sensitive Lipase Polyclonal Antibody

货号： 10006371-500      产品名称： Hormone Sensitive Lipase Polyclonal Antibody   品牌： Cayman 规格： 500 碌l 3周

Melanocortin-4 Receptor Blocking Peptide
Cayman Chemical Item Number 10006356
Description
Antigen:synthetic peptide from human HSL amino acids 731-741 (LCRETRQAAEL) · Host:rabbit · Application(s):WB ; other applications not tested · Hormone sensitive lipase (HSL) catalyzes the hydrolysis of tri-, di-, and monoacylglycerols, as well as cholesterol esters and thus mobilizes fatty acid and provides a primary source of energy in mammals.1↗ The enzyme is highly expressed in adipose tissue and steroidogenic tissues, and less abundantly in skeletal muscle, heart, brain, pancreatic beta cells, adrenal gland, ovaries, testes, and macrophages. Its presence in various tissues indicates the enzyme plays diverse roles including those in steroidogenesis and spermatogenesis, foam cell formation in atherosclerosis, and diabetic pathology.1↗,2↗ Human HSL cDNA encodes a 775 amino acid protein with an estimated molecular size of 84 kDa.3↗ A second, larger isoform encoded by a unique testis mRNA was later identified.4↗,5↗ Cayman’s HSL polyclonal antibody detects the enzyme at 86 kDa by western blotting from adipose tissue.
Synonyms LIPE HSL
Formal Name
Formulation Peptide affinity-purified IgG
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Specificity
Human HSL
Mouse HSL
Ovine HSL

-20°C