IRSp53, RBX-100uL

货号： 07-786      产品名称： IRSp53, RBX-100uL   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-IRSp53 Antibody
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REFERENCES
Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac
Suetsugu, Shiro, et al (2006) J Cell Biol, 173:571-85 (2006)
Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPases
Choi, Jeonghoon, et al (2005) J Neurosci, 25:869-79 (2005)
A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein
Yamagishi, Akiko, et al (2004) J Biol Chem, 279:14929-36 (2004)
Species Reactivity Key Applications Host Format Antibody Type
H, M, R  WB Rabbit Serum Polyclonal Antibody
Description:
Anti-IRSp53 Antibody
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes IRSp53
Molecular Weight:
53 kDa
Immunogen:
Peptide corresponding to amino acids 293-380 of human IRSp53.
Species Reactivity:
Human
Mouse
Rat
Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Serum
Storage Conditions:
2 years at -20°C from date of shipment
UniProt Number:
Q9UQB8
Entrez Gene Number:
NM_006340.1
NM_017450.1
NM_017451.1
Gene Symbol:
BAIAP2
IRSP53
IRSp53/58
IRSp53
IRS-58
BAP2
FLAF3
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Alternate Names:
insulin receptor substrate p53, BAP2, BAIAP2, BAI1-associated protein 2,
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This interaction at the cytoplasmic membrane is crucial to the function of this protein, which may be involved in neuronal growth-cone guidance. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. Alternative splicing of the 3′-end of this gene results in three products of undetermined function.
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UniProt Summary:
FUNCTION: SwissProt: Q9UQB8 # Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation.
SIZE: 552 amino acids; 60868 Da
SUBUNIT: Homodimer. Interacts with CDC42 and RAC1 that have been activated by GTP binding. Interacts with ATN1, BAI1, EPS8, SHANK1, SHANK2, SHANK3, WASF1 and WASF2. Interacts with ENAH after recruitment of CDC42. Interacts with TIAM1 and DIAPH1 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm. Membrane; P -20℃