INTERNEXIN (ALPHA), RB X-50UL

货号： AB5354      产品名称： INTERNEXIN (ALPHA), RB X-50UL   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-Internexin α Antibody
Close
REFERENCES
Spatial and temporal requirements for sonic hedgehog in the regulation of thalamic interneuron identity.
Jeong, Yongsu, et al. (2011) Development, 138: 531-41 (2011)
Characterization of mitotic neurons derived from adult rat hypothalamus and brain stem
Evans, J. et al. (2002) Journal of Neurophysiology, 87:1076-1085 (2002)
Species Reactivity Key Applications Host Format Antibody Type
Ma  ELISA, WB, ICC, IHC Rabbit Serum Polyclonal Antibody
Description:
Anti-Internexin α Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Chemicon (Millipore)
Specificity:
alpha-internexin, C-terminal globular "tail" region. By western blot, AB5354 detects a major band at 66 kDa and a minor band at approximately 150 kDa corresponding to alpha internexin monomer and dimer, respectively. A minor band at approximately 50 kDa is occasionally detected and is believed to be a degradation product of alpha internexin. This antibody has been referred to in the literature as the R36 antibody (Evans, 2002).
View All »
Immunogen:
Full length recombinant rat alpha-internexin fused to E. coli Trp E.
Species Reactivity:
Mammals
Application Notes:
Immunohistochemistry on formalin or paraformaldehyde fixed tissues.
Immunocytochemistry.
Western blot: using human or rat brain homogenates.
ELISA
Optimal working dilutions must be determined by end user.
View All »
Control:
POSITIVE CONTROL CELLS: PC12, Ntera2.
Presentation:
Serum liquid, containing no preservatives.
Storage Conditions:
Maintain frozen at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
UniProt Number:
Q16352
Entrez Gene Number:
NM_032727.2
Gene Symbol:
INA
NF-66
NEF5
MGC12702
Alpha-Inx
TXBP-1
Neurofilament-66
Alpha-internexin
View All »
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
ELISA
Western Blotting
Immunocytochemistry
Immunohistochemistry
UniProt Summary:
FUNCTION: SwissProt: Q16352 # Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges.
SIZE: 499 amino acids; 55391 Da
TISSUE SPECIFICITY: Found predominantly in adult CNS.
DEVELOPMENTAL STAGE: Expressed in brain as early as the 16th week of gestation, and increased rapidly and reached a steady state level by the 18th week of gestation.
PTM: O-glycosylated (By similarity). & Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: SwissProt: Q16352 ## Belongs to the intermediate filament family.
View All »
Brand Family:
Chemicon
Product Name:
Anti-Internexin α Antibody
Antibody Type:
Polyclonal Antibody
Qty/Pk:
50 µL
Target / Localization:
Cytoplasmic, soma, early neurites
Format:
Serum -20℃