MYD88 (INTERNAL), RB X-100UG

货号： AB16529      产品名称： MYD88 (INTERNAL), RB X-100UG   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-MyD88 Antibody, internal sequence
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REFERENCES
Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity.
Kawai, T, et al. (1999) Oncogene, 18: 3471-80 (1999)
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways.
Medzhitov, R, et al. (1998) Mol. Cell, 2: 253-8 (1998)
IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.
Muzio, M, et al. (1997) Science, 278: 1612-5 (1997)
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.
Adachi, O, et al. (1998) Immunity, 9: 143-50 (1998)
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Species Reactivity Key Applications Host Format Antibody Type
H, M  WB Rabbit Purified Polyclonal Antibody
Description:
Anti-MyD88 Antibody, internal sequence
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Trade Name:
Chemicon (Millipore)
Specificity:
The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-RAcP. Recently, MyD88 was identified as an adapter molecule in the IL-1 signaling pathway (Muzio et al. 1997). MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R mediated NF-kB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor (Adachi et al. 1998; Medzhitov et al. 1998), which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in loss of cellular responses to IL-1 and IL-18, and MyD88-defecient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.
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Epitope:
internal sequence
Immunogen:
Rabbit anti-MyD88 (internal) polyclonal antibody was raised against a peptide corresponding to amino acids 233 to 248 of human MyD88 (Bonnert et al. 1997), which differ from those of mouse by two amino acids.
Species Reactivity:
Human
Mouse
Application Notes:
Western blot: 1:500 to 1:1000
Whole cell lysate from Jurkat cells can be used as positive control and a 35 kDa band should be detected.
AB16529 cross reacts with mouse.
Optimal working dilutions must be determined by end user.
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Presentation:
Purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.
Storage Conditions:
Maintain at 2-8°C in undiluted aliquots for up to 12 months.
UniProt Number:
Q99836
Entrez Gene Number:
NM_002468.3
Gene Symbol:
MYD88
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
UniProt Summary:
FUNCTION: SwissProt: Q99836 # Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 2-8℃