标签： gtp

0215121610   Guanosine 5′-Triphosphate Sodium Salt Hydrate （GTP）/鸟苷-5′-三磷酸三钠盐(GTP)   品牌 MPbio

Guanosine 5′-Triphosphate Sodium Salt Hydrate （GTP）/鸟苷-5′-三磷酸三钠盐(GTP)

货号： 0215121610      产品名称： Guanosine 5′-Triphosphate Sodium Salt Hydrate （GTP）/鸟苷-5′-三磷酸三钠盐(GTP)   品牌： MPbio 规格： 10 mg

324892-10MG   eIF2–GTP–tRNAiMetTernaryCompInhib,BTdCPU   品牌 Merck

eIF2–GTP–tRNAiMetTernaryCompInhib,BTdCPU

货号： 324892-10MG      产品名称： eIF2–GTP–tRNAiMetTernaryCompInhib,BTdCPU   品牌： Merck 规格： *** 3周到货 生化实验

eIF2-GTP-tRNAiMet ternary complex Inhibitor, BTdCPU
1-(benzo[d][1,2,3]thiadiazol-6-yl)-3-(3,4-dichlorophenyl)urea, N,N’-diarylurea;translation initiation tenrary complex inhibitor, heme-regulated inhibitor kinase activator, BTdCPU, BTdCPU
A cell-permeable N, N’-diarylurea that acts as an inhibitor of the formation of the ternary complex of eukaryotic translation initiation factor 2 (eIF2), GTP and the initiator methionine tRNA (Met-tRNAi), a key regulatory step of translation initiation. It directly activates heme-regulated inhibitor kinase (HRI), which then phosphorylates eIF2α in cells at 10 µM and in cell-free extracts dose-dependently, and thereby prevents respective ternary complex formation without elevating oxidative stress. The sensitivities of various cancer cell lines to the anti-proliferative effects of this compound are shown to correlate with the expression of HRI. Furthermore, this compound displays tumor growth inhibition in a mice xenograft model of MCF-7 human breast cancer cells at 175 mg/kg, in vivo.
产品信息
Form  White solid
Molar mass  339.2
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥99% by HPLC
Solubility  DMSO
Chemical formula  C13H8Cl2N4OS
CAS number  1257423-87-2
商店和运输信息
Storage  +2°C to +8°C
Ship  Ambient Temperature Only
Standard Handling

2°C – 8°C

324889-10MG   eIF2–GTP–tRNAiMetTernaryCompInhibNCPdCPU   品牌 Merck

eIF2–GTP–tRNAiMetTernaryCompInhibNCPdCPU

货号： 324889-10MG      产品名称： eIF2–GTP–tRNAiMetTernaryCompInhibNCPdCPU   品牌： Merck 规格： *** 3周到货 生化实验

eIF2-GTP-tRNAiMet ternary complex Inhibitor Negative Control, NCPdCPU
A negative control for eIF2-GTP-tRNAiMet ternary complex Inhibitor, BTdCPU.
产品信息
Form  Yellow solid
Molar mass  360.58
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥99% by HPLC
Solubility  DMSO
Chemical formula  C13H8Cl3N3O3
商店和运输信息
Storage  +2°C to +8°C
Ship  Ambient Temperature Only
Standard Handling

2°C – 8°C

ABD37   Anti-REM 2 (GTP-binding protein)   品牌 Millipore

Anti-REM 2 (GTP-binding protein)

货号： ABD37      产品名称： Anti-REM 2 (GTP-binding protein)   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-REM 2 (GTP-binding protein)
Species Reactivity Key Applications Host Format Antibody Type
H, M  WB, ICC Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-REM 2 (GTP-binding protein) Antibody
Promotional Text:
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100% Performance Guaranteed
Specificity:
This antibody recognizes the C-terminus of REM2.
Molecular Weight:
~42 kDa observed. The calculated molecular weight is 37 kDa, however REM2 has been shown as a ~42 kDa band in western blots (Finlin, B., et al. (2000). Biochem. J. 347:223-231.). An uncharacterized band appears at ~62 kDa in some lysates.
Epitope:
C-terminus
Immunogen:
KLH-conjugated linear peptide corresponding to the C-terminus of human REM2.
Background Information:
The GTP-binding protein REM 2 (REM2) is a member of the RGK subfamily of Ras-like GTPases. REM2 is highly expressed in the brain and may have multiple related effects on neural function. Previous studies have demonstrated that REM2 may play a role in the development of both GABAergic and glutamatergic synapses. It has also been reported that REM2 is required specifically for the maturation of dendritic spines and may affect calcium homeostasis through inhibition of voltage-gated Ca2+ channels.
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Species Reactivity:
Human
Mouse
Species Reactivity Note:
Demonstrated to react with Human and Mouse. Predicted to react with Rat and Bovine based on 100% sequence homology.
Application Notes:
Western Blot Analysis: 0.5 µg/mLfrom a representative lot detected REM2 on 10 µg of human heart tissue lysate.
Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected REM2 in NIH/3T3, A431, and HeLa cells.
Control:
Human kidney tissue lysate
Quality Assurance:
Evaluated by Western Blot in human kidney tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected REM2 on 10 µg of human kidney tissue lysate.
Purification Method:
Affinity purified
Presentation:
Purified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
Q8IYK8
Entrez Gene Number:
NP_775798
Gene Symbol:
REM2
Alternate Names:
GTP-binding protein REM 2
Rad and Gem-like GTP-binding protein 2
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Immunocytochemistry
Product Name:
Anti-REM 2 (GTP-binding protein)
Concentration:
Please refer to the Certificate of Analysis for the lot-specific concentration.
Antibody Type:
Polyclonal Antibody
Qty/Pk:
100 μg
Format:
Affinity Purified
Host:
Rabbit
Applications:
Anti-REM 2 (GTP-binding protein) Antibody is an antibody against REM 2 (GTP-binding protein) for use in Western Blotting, ICC.

2-8℃

07-2128   Anti-Nucleolar GTP-binding protein 1   品牌 Millipore

Anti-Nucleolar GTP-binding protein 1

货号： 07-2128      产品名称： Anti-Nucleolar GTP-binding protein 1   品牌： Millipore 规格： EA 3周到货 生化实验

Anti-Nucleolar GTP-binding protein 1 Antibody
Description:
Anti-Nucleolar GTP-binding protein 1 Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Specificity:
This antibody recognizes Nucleolar GTP-binding protein 1
Molecular Weight:
74 kDa
Epitope:
Unknown
Immunogen:
GST-tagged recombinant protein corresponding to human Nucleolar GTP-binding protein 1.
Background Information:
GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. ‘Active’ in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.
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Species Reactivity:
Human
Rat
Mouse
Species Reactivity Note:
Proven to react with human, mouse, and rat.
Control:
Hek293 cell lysate
Quality Assurance:
Evaluated by Western Blot in Hek293 cell lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected Nucleolar GTP-binding protein 1 in Hek293 cell lysate.
Purification Method:
Unpurified
Presentation:
Unpurified rabbit serum with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
UniProt Number:
Q9BZE4
Entrez Gene Number:
NP_036473.2
Gene Symbol:
GTPBP4
CRFG
NGB
NOG1
Alternate Names:
Chronic renal failure gene protein
G protein-binding protein CRFG
GTP binding protein 4
GTP-binding protein
GTP-binding protein NGB
chronic renal failure
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. ‘Active’ in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.
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UniProt Summary:
FUNCTION: Involved in the biogenesis of the 6 2°C – 8°C