标签： gdc

1623-1   GDC-0941   品牌 Biovision

GDC-0941

货号： 1623-1      产品名称： GDC-0941   品牌： Biovision 规格： 1 mg 3周到货 生化实验

GDC-0941
Product Overview
Product Name: GDC-0941
Alternate Name/Synonyms: 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-thieno[3,2- d]pyrimidine
Description: GDC-0941 is a potent inhibitor of p110α and p110δ (IC₅₀ = 3 nM). It selectively binds to PI3K isoforms in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway.
Peptide Sequence: N/A
Appearance: Off-white solid
Formulation: N/A
CAS Number: 957054-30-7
Molecular Formula: C₂₃H₂₇N₇O₃S₂
Molecular Weight: 513.64
Purity: ≥99% by HPLC
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: RT
Handling: Protect from air and light
SMILES: CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6
InChi: InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27)
InChi Key: LHNIIDJUOCFXAP-UHFFFAOYSA-N
PubChem CID: 17755052
MDL Number: MFCD11616196
USAGE: For Research Use Only! Not For Use in Humans.

-20°C

1623-5   GDC-0941   品牌 Biovision

GDC-0941

货号： 1623-5      产品名称： GDC-0941   品牌： Biovision 规格： 5 mg 3周到货 生化实验

GDC-0941
Product Overview
Product Name: GDC-0941
Alternate Name/Synonyms: 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-thieno[3,2- d]pyrimidine
Description: GDC-0941 is a potent inhibitor of p110α and p110δ (IC₅₀ = 3 nM). It selectively binds to PI3K isoforms in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway.
Peptide Sequence: N/A
Appearance: Off-white solid
Formulation: N/A
CAS Number: 957054-30-7
Molecular Formula: C₂₃H₂₇N₇O₃S₂
Molecular Weight: 513.64
Purity: ≥99% by HPLC
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: RT
Handling: Protect from air and light
SMILES: CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6
InChi: InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27)
InChi Key: LHNIIDJUOCFXAP-UHFFFAOYSA-N
PubChem CID: 17755052
MDL Number: MFCD11616196
USAGE: For Research Use Only! Not For Use in Humans.

-20°C

1890-5   GDC-0449   品牌 Biovision

GDC-0449

货号： 1890-5      产品名称： GDC-0449   品牌： Biovision 规格： 5 mg 3周到货 生化实验

GDC-0449
A Smoothened (Smo) antagonist
Product Overview
Product Name: GDC-0449
Alternate Name/Synonyms: 2-Chloro-N-(4-chloro-3-(pyridine-2-yl)phenyl)-4-(methylsulfonyl)benzamide; HhAntag691
Description: A potent inhibitor of Smoothened (SMO), a key mediator of Hedgehog (Hh) signaling pathway. Inhibition of SMO renders the transcription factor GLI inactive, thus preventing the expression of genes that mediate the role of Hh on tumor growth.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 879085-55-9
Molecular Formula: C₁₉H₁₄Cl₂N₂O₃S
Molecular Weight: 421.3
Purity: ≥98% by HPLC
Solubility:DMSO (200 mg/ml) or EtOH (10 mg/ml with warming)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
InChi: InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24)
InChi Key: BPQMGSKTAYIVFO-UHFFFAOYSA-N
PubChem CID: 24776445
MDL Number: MFCD12407408
USAGE: For Research Use Only! Not For Use in Humans.

-20°C

1890-25   GDC-0449   品牌 Biovision

GDC-0449

货号： 1890-25      产品名称： GDC-0449   品牌： Biovision 规格： 25 mg 3周到货 生化实验

GDC-0449
A Smoothened (Smo) antagonist
Product Overview
Product Name: GDC-0449
Alternate Name/Synonyms: 2-Chloro-N-(4-chloro-3-(pyridine-2-yl)phenyl)-4-(methylsulfonyl)benzamide; HhAntag691
Description: A potent inhibitor of Smoothened (SMO), a key mediator of Hedgehog (Hh) signaling pathway. Inhibition of SMO renders the transcription factor GLI inactive, thus preventing the expression of genes that mediate the role of Hh on tumor growth.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 879085-55-9
Molecular Formula: C₁₉H₁₄Cl₂N₂O₃S
Molecular Weight: 421.3
Purity: ≥98% by HPLC
Solubility:DMSO (200 mg/ml) or EtOH (10 mg/ml with warming)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
InChi: InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24)
InChi Key: BPQMGSKTAYIVFO-UHFFFAOYSA-N
PubChem CID: 24776445
MDL Number: MFCD12407408
USAGE: For Research Use Only! Not For Use in Humans.

-20°C

G-9252-1 g   GDC-0941, Free Base   品牌 LC

GDC-0941, Free Base

货号： G-9252-1 g      产品名称： GDC-0941, Free Base   品牌： LC 规格： 1 g

G-9252 GDC-0941, Free Base, >99%[New Generic Name: Pictilisib]M.W. 513.64 C23H27N7O3S2 [957054-30-7] Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 66 mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 µM buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A •GDC-0941 is a phosphatidylinositol 3-kinase (PI3K) inhibitor. Folkes, A.J., et al. “The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer.” J. Med. Chem. 51: 5522-5532 (2008). •GDC-0941 inhibited the growth of >70% of breast cancer cell lines tested, with EC50’s <1 µm. gdc-0941 also demonstrated antitumor activity in preclinical models of breast cancer. yao, e., et al. "suppression her2>

G-9252-100 mg   GDC-0941, Free Base   品牌 LC

GDC-0941, Free Base

货号： G-9252-100 mg      产品名称： GDC-0941, Free Base   品牌： LC 规格： 100 mg

G-9252 GDC-0941, Free Base, >99%[New Generic Name: Pictilisib]M.W. 513.64 C23H27N7O3S2 [957054-30-7] Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 66 mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 µM buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A •GDC-0941 is a phosphatidylinositol 3-kinase (PI3K) inhibitor. Folkes, A.J., et al. “The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer.” J. Med. Chem. 51: 5522-5532 (2008). •GDC-0941 inhibited the growth of >70% of breast cancer cell lines tested, with EC50’s <1 µm. gdc-0941 also demonstrated antitumor activity in preclinical models of breast cancer. yao, e., et al. "suppression her2>

G-9252-200 mg   GDC-0941, Free Base   品牌 LC

GDC-0941, Free Base

货号： G-9252-200 mg      产品名称： GDC-0941, Free Base   品牌： LC 规格： 200 mg

G-9252 GDC-0941, Free Base, >99%[New Generic Name: Pictilisib]M.W. 513.64 C23H27N7O3S2 [957054-30-7] Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 66 mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 µM buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A •GDC-0941 is a phosphatidylinositol 3-kinase (PI3K) inhibitor. Folkes, A.J., et al. “The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer.” J. Med. Chem. 51: 5522-5532 (2008). •GDC-0941 inhibited the growth of >70% of breast cancer cell lines tested, with EC50’s <1 µm. gdc-0941 also demonstrated antitumor activity in preclinical models of breast cancer. yao, e., et al. "suppression her2>

G-9252-25 mg   GDC-0941, Free Base   品牌 LC

GDC-0941, Free Base

货号： G-9252-25 mg      产品名称： GDC-0941, Free Base   品牌： LC 规格： 25 mg

G-9252 GDC-0941, Free Base, >99%[New Generic Name: Pictilisib]M.W. 513.64 C23H27N7O3S2 [957054-30-7] Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 66 mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 µM buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A •GDC-0941 is a phosphatidylinositol 3-kinase (PI3K) inhibitor. Folkes, A.J., et al. “The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer.” J. Med. Chem. 51: 5522-5532 (2008). •GDC-0941 inhibited the growth of >70% of breast cancer cell lines tested, with EC50’s <1 µm. gdc-0941 also demonstrated antitumor activity in preclinical models of breast cancer. yao, e., et al. "suppression her2>

G-9252-50 mg   GDC-0941, Free Base   品牌 LC

GDC-0941, Free Base

货号： G-9252-50 mg      产品名称： GDC-0941, Free Base   品牌： LC 规格： 50 mg

G-9252 GDC-0941, Free Base, >99%[New Generic Name: Pictilisib]M.W. 513.64 C23H27N7O3S2 [957054-30-7] Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 66 mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 µM buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A •GDC-0941 is a phosphatidylinositol 3-kinase (PI3K) inhibitor. Folkes, A.J., et al. “The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer.” J. Med. Chem. 51: 5522-5532 (2008). •GDC-0941 inhibited the growth of >70% of breast cancer cell lines tested, with EC50’s <1 µm. gdc-0941 also demonstrated antitumor activity in preclinical models of breast cancer. yao, e., et al. "suppression her2>

G-9252-500 mg   GDC-0941, Free Base   品牌 LC

GDC-0941, Free Base

货号： G-9252-500 mg      产品名称： GDC-0941, Free Base   品牌： LC 规格： 500 mg

G-9252 GDC-0941, Free Base, >99%[New Generic Name: Pictilisib]M.W. 513.64 C23H27N7O3S2 [957054-30-7] Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 66 mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 µM buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A •GDC-0941 is a phosphatidylinositol 3-kinase (PI3K) inhibitor. Folkes, A.J., et al. “The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer.” J. Med. Chem. 51: 5522-5532 (2008). •GDC-0941 inhibited the growth of >70% of breast cancer cell lines tested, with EC50’s <1 µm. gdc-0941 also demonstrated antitumor activity in preclinical models of breast cancer. yao, e., et al. "suppression her2>