标签归档：garcinol

2088-5   Garcinol   品牌 Biovision

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Garcinol

货号： 2088-5      产品名称： Garcinol   品牌： Biovision 规格： 5 mg 3周到货 生化实验

Garcinol
A potent histone acetyltransferases (HATs) p300 inhibitor
Product Overview
Product Name: Garcinol
Alternate Name/Synonyms: Camboginol
Description: Garcinol is a polyisoprenylated benzophenone derivative isolated from Garcinia indica. It is a potent inhibitor of histone acetyltransferases (HATs) p300 (IC50 = 7 µM) and PCAF (IC50 = 5 µM) both in vitro and in vivo. HAT activity-dependent chromatin transcription was inhibited by garcinol, but it had no effect on naked DNA transcription. Moreover, it induces apoptosis in several types of cancer cells and has anti-inflammatory actions. Garcinol promotes neurogenesis and ex vivo expansion of human hematopoietic stem cells.
Peptide Sequence: N/A
Appearance: Yellow solid
Formulation: N/A
CAS Number: 78824-30-3
Molecular Formula: C₃₈H₅₀O₆
Molecular Weight: 602.8
Purity: ≥95% by TLC
Solubility:DMSO (25 mg/ml) or EtOH (25 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: CC(=CCC1CC2(C(=O)C(=C(C3=CC(=C(C=C3)O)O)O)C(=O)C(C2=O)(C1(C)C)CC=C(C)C)CC(CC=C(C)C)C(=C)C)C
InChi: InChI=1S/C38H50O6/c1-22(2)11-13-27(25(7)8)20-37-21-28(15-12-23(3)4)36(9,10)38(35(37)44,18-17-24(5)6)34(43)31(33(37)42)32(41)26-14-16-29(39)30(40)19-26/h11-12,14,16-17,19,27-28,39-41H,7,13,15,18,20-21H2,1-6,8-10H3
InChi Key: DTTONLKLWRTCAB-UHFFFAOYSA-N
PubChem CID: 3531
MDL Number: MFCD03700761
USAGE: For Research Use Only! Not For Use in Humans.

-20°C

2088-25   Garcinol   品牌 Biovision

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Garcinol

货号： 2088-25      产品名称： Garcinol   品牌： Biovision 规格： 25 mg 3周到货 生化实验

Garcinol
A potent histone acetyltransferases (HATs) p300 inhibitor
Product Overview
Product Name: Garcinol
Alternate Name/Synonyms: Camboginol
Description: Garcinol is a polyisoprenylated benzophenone derivative isolated from Garcinia indica. It is a potent inhibitor of histone acetyltransferases (HATs) p300 (IC50 = 7 µM) and PCAF (IC50 = 5 µM) both in vitro and in vivo. HAT activity-dependent chromatin transcription was inhibited by garcinol, but it had no effect on naked DNA transcription. Moreover, it induces apoptosis in several types of cancer cells and has anti-inflammatory actions. Garcinol promotes neurogenesis and ex vivo expansion of human hematopoietic stem cells.
Peptide Sequence: N/A
Appearance: Yellow solid
Formulation: N/A
CAS Number: 78824-30-3
Molecular Formula: C₃₈H₅₀O₆
Molecular Weight: 602.8
Purity: ≥95% by TLC
Solubility:DMSO (25 mg/ml) or EtOH (25 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: CC(=CCC1CC2(C(=O)C(=C(C3=CC(=C(C=C3)O)O)O)C(=O)C(C2=O)(C1(C)C)CC=C(C)C)CC(CC=C(C)C)C(=C)C)C
InChi: InChI=1S/C38H50O6/c1-22(2)11-13-27(25(7)8)20-37-21-28(15-12-23(3)4)36(9,10)38(35(37)44,18-17-24(5)6)34(43)31(33(37)42)32(41)26-14-16-29(39)30(40)19-26/h11-12,14,16-17,19,27-28,39-41H,7,13,15,18,20-21H2,1-6,8-10H3
InChi Key: DTTONLKLWRTCAB-UHFFFAOYSA-N
PubChem CID: 3531
MDL Number: MFCD03700761
USAGE: For Research Use Only! Not For Use in Humans.

-20°C

BML-GR343-0010   Garcinol|正品原装   品牌 Biomol

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Garcinol|正品原装

货号： BML-GR343-0010      产品名称： Garcinol|正品原装   品牌： Biomol 规格： 10 mg 期货 生化实验

Garcinol|Biomol BML-GR343-0010|原装热销 
产品说明：
Formula: C38H50O6
MW: 602.8
CAS: 78824-30-3
Purity: ≥95% (TLC)
Appearance: Yellow Solid
Solubility: Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml) or dimethylformamide (25mg/ml) or water (nil)
Long Term Storage: -20°C
简介：
Garcinol is a polyisoprenylated benzophenone derivative isolated from Garcinia indica. It is a potent inhibitor of histone acetyltransferases (HATs) p300 (IC50=7µM) and PCAF (IC50=5µM) both in vitro and in vivo. HAT activity-dependent chromatin transcription was inhibited by garcinol, but it had no effect on naked DNA transcription. It induces apoptosis in HeLa cells (100µM) where it down regulates global gene expression. Acetylation of histone H4 by p300 was more sensitive to inhibition by garcinol compared with that of H3. more
Histone H4 acetylation was completely inhibited at 1 M while acetylation of H3 was not abolished at 20 µM1

-20°C

BML-GR343-0050   热销正品|Garcinol   品牌 Biomol

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热销正品|Garcinol

货号： BML-GR343-0050      产品名称： 热销正品|Garcinol   品牌： Biomol 规格： 50 mg 期货 生化实验

Garcinol|Biomol BML-GR343-0050|原装热销 
产品说明：
Formula: C38H50O6
MW: 602.8
CAS: 78824-30-3
Purity: ≥95% (TLC)
Appearance: Yellow Solid
Solubility: Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml) or dimethylformamide (25mg/ml) or water (nil)
Long Term Storage: -20°C
简介：
Garcinol is a polyisoprenylated benzophenone derivative isolated from Garcinia indica. It is a potent inhibitor of histone acetyltransferases (HATs) p300 (IC50=7µM) and PCAF (IC50=5µM) both in vitro and in vivo. HAT activity-dependent chromatin transcription was inhibited by garcinol, but it had no effect on naked DNA transcription. It induces apoptosis in HeLa cells (100µM) where it down regulates global gene expression. Acetylation of histone H4 by p300 was more sensitive to inhibition by garcinol compared with that of H3. more
Histone H4 acetylation was completely inhibited at 1 M while acetylation of H3 was not abolished at 20 µM1

-20°C

10566-1   Garcinol   品牌 Cayman

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Garcinol

货号： 10566-1      产品名称： Garcinol   品牌： Cayman 规格： 1 mg 3周

Garcinol Cayman Chemical Item Number 10566 Description Garcinol is an inhibitor of the histone acetyltransferases (HATs) p300 and PCAF (IC50 = 7 and 5 μM, respectively).1↗ It also inhibits the HAT GCN5 in Cryptococcus neoformans, inducing temperature sensitivity and impairing growth.2↗ A polyisoprenylated benzophenone isolated from Garcinia indica, garcinol promotes neurogenesis and ex vivo expansion of human hematopoietic stem cells.3↗,4↗ Moreover, it induces apoptosis in several types of cancer cells and has anti-inflammatory actions.5↗,6↗ Synonyms Camboginol Formal Name 3-​(3,​4-​dihydroxybenzoyl)-​4-​hydroxy-​8,​8-​dimethyl-​1,​7-​bis(3-​methyl-​2-​buten-​1-​yl)-​5-​[(2S)-​5-​methyl-​2-​(1-​methylethenyl)-​4-​hexen-​1-​yl]-​bicyclo[3.3.1]non-​3-​ene-​2,​9-​dione CAS Number 78824-30-3 Molecular Formula C38H50O6 Formula Weight 602.8 Formulation A crystalline solid Purity ≥95% λmax 252, 364 nm Stability 2 years Storage -20°C Shipping Wet ice in continental US; may vary elsewhere SMILES CC([C@H]​(C/C=C(C)​/C)​C[C@]​1(C[C@@H]​(C(C)​=C)​C/C=C(C)​C)​C(O)​=C2C(C3=CC(O)​=C(O)​C=C3)​=O)​(C)​[C@]​(C/C=C(C)​C)​(C1=O)​C2=O InCHI Code ​1S/C38H50O6/c1-22(2)​11-13-27(25(7)​8)​20-37-21-28(15-12-23(3)​4)​36(9,10)​38(35(37)​44,18-17-24(5)​6)​34(43)​31(33(37)​42)​32(41)​26-14-16-29(39)​30(40)​19-26/h11-12,14,16-17,19,27-28,39-40,42H,7,13,15,18,20-21H2,1-6,8-10H3/t27-,28+,37+,38-/m0/s1 InCHI Key QDKLRKZQSOQWJQ-SMDXAGPFSA-N -20°C

10566-10   Garcinol   品牌 Cayman

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Garcinol

货号： 10566-10      产品名称： Garcinol   品牌： Cayman 规格： 10 mg 3周

Garcinol Cayman Chemical Item Number 10566 Description Garcinol is an inhibitor of the histone acetyltransferases (HATs) p300 and PCAF (IC50 = 7 and 5 μM, respectively).1↗ It also inhibits the HAT GCN5 in Cryptococcus neoformans, inducing temperature sensitivity and impairing growth.2↗ A polyisoprenylated benzophenone isolated from Garcinia indica, garcinol promotes neurogenesis and ex vivo expansion of human hematopoietic stem cells.3↗,4↗ Moreover, it induces apoptosis in several types of cancer cells and has anti-inflammatory actions.5↗,6↗ Synonyms Camboginol Formal Name 3-​(3,​4-​dihydroxybenzoyl)-​4-​hydroxy-​8,​8-​dimethyl-​1,​7-​bis(3-​methyl-​2-​buten-​1-​yl)-​5-​[(2S)-​5-​methyl-​2-​(1-​methylethenyl)-​4-​hexen-​1-​yl]-​bicyclo[3.3.1]non-​3-​ene-​2,​9-​dione CAS Number 78824-30-3 Molecular Formula C38H50O6 Formula Weight 602.8 Formulation A crystalline solid Purity ≥95% λmax 252, 364 nm Stability 2 years Storage -20°C Shipping Wet ice in continental US; may vary elsewhere SMILES CC([C@H]​(C/C=C(C)​/C)​C[C@]​1(C[C@@H]​(C(C)​=C)​C/C=C(C)​C)​C(O)​=C2C(C3=CC(O)​=C(O)​C=C3)​=O)​(C)​[C@]​(C/C=C(C)​C)​(C1=O)​C2=O InCHI Code ​1S/C38H50O6/c1-22(2)​11-13-27(25(7)​8)​20-37-21-28(15-12-23(3)​4)​36(9,10)​38(35(37)​44,18-17-24(5)​6)​34(43)​31(33(37)​42)​32(41)​26-14-16-29(39)​30(40)​19-26/h11-12,14,16-17,19,27-28,39-40,42H,7,13,15,18,20-21H2,1-6,8-10H3/t27-,28+,37+,38-/m0/s1 InCHI Key QDKLRKZQSOQWJQ-SMDXAGPFSA-N -20°C

10566-25   Garcinol   品牌 Cayman

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Garcinol

货号： 10566-25      产品名称： Garcinol   品牌： Cayman 规格： 25 mg 3周

Garcinol Cayman Chemical Item Number 10566 Description Garcinol is an inhibitor of the histone acetyltransferases (HATs) p300 and PCAF (IC50 = 7 and 5 μM, respectively).1↗ It also inhibits the HAT GCN5 in Cryptococcus neoformans, inducing temperature sensitivity and impairing growth.2↗ A polyisoprenylated benzophenone isolated from Garcinia indica, garcinol promotes neurogenesis and ex vivo expansion of human hematopoietic stem cells.3↗,4↗ Moreover, it induces apoptosis in several types of cancer cells and has anti-inflammatory actions.5↗,6↗ Synonyms Camboginol Formal Name 3-​(3,​4-​dihydroxybenzoyl)-​4-​hydroxy-​8,​8-​dimethyl-​1,​7-​bis(3-​methyl-​2-​buten-​1-​yl)-​5-​[(2S)-​5-​methyl-​2-​(1-​methylethenyl)-​4-​hexen-​1-​yl]-​bicyclo[3.3.1]non-​3-​ene-​2,​9-​dione CAS Number 78824-30-3 Molecular Formula C38H50O6 Formula Weight 602.8 Formulation A crystalline solid Purity ≥95% λmax 252, 364 nm Stability 2 years Storage -20°C Shipping Wet ice in continental US; may vary elsewhere SMILES CC([C@H]​(C/C=C(C)​/C)​C[C@]​1(C[C@@H]​(C(C)​=C)​C/C=C(C)​C)​C(O)​=C2C(C3=CC(O)​=C(O)​C=C3)​=O)​(C)​[C@]​(C/C=C(C)​C)​(C1=O)​C2=O InCHI Code ​1S/C38H50O6/c1-22(2)​11-13-27(25(7)​8)​20-37-21-28(15-12-23(3)​4)​36(9,10)​38(35(37)​44,18-17-24(5)​6)​34(43)​31(33(37)​42)​32(41)​26-14-16-29(39)​30(40)​19-26/h11-12,14,16-17,19,27-28,39-40,42H,7,13,15,18,20-21H2,1-6,8-10H3/t27-,28+,37+,38-/m0/s1 InCHI Key QDKLRKZQSOQWJQ-SMDXAGPFSA-N -20°C

10566-5   Garcinol   品牌 Cayman

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Garcinol

货号： 10566-5      产品名称： Garcinol   品牌： Cayman 规格： 5 mg 3周

Garcinol Cayman Chemical Item Number 10566 Description Garcinol is an inhibitor of the histone acetyltransferases (HATs) p300 and PCAF (IC50 = 7 and 5 μM, respectively).1↗ It also inhibits the HAT GCN5 in Cryptococcus neoformans, inducing temperature sensitivity and impairing growth.2↗ A polyisoprenylated benzophenone isolated from Garcinia indica, garcinol promotes neurogenesis and ex vivo expansion of human hematopoietic stem cells.3↗,4↗ Moreover, it induces apoptosis in several types of cancer cells and has anti-inflammatory actions.5↗,6↗ Synonyms Camboginol Formal Name 3-​(3,​4-​dihydroxybenzoyl)-​4-​hydroxy-​8,​8-​dimethyl-​1,​7-​bis(3-​methyl-​2-​buten-​1-​yl)-​5-​[(2S)-​5-​methyl-​2-​(1-​methylethenyl)-​4-​hexen-​1-​yl]-​bicyclo[3.3.1]non-​3-​ene-​2,​9-​dione CAS Number 78824-30-3 Molecular Formula C38H50O6 Formula Weight 602.8 Formulation A crystalline solid Purity ≥95% λmax 252, 364 nm Stability 2 years Storage -20°C Shipping Wet ice in continental US; may vary elsewhere SMILES CC([C@H]​(C/C=C(C)​/C)​C[C@]​1(C[C@@H]​(C(C)​=C)​C/C=C(C)​C)​C(O)​=C2C(C3=CC(O)​=C(O)​C=C3)​=O)​(C)​[C@]​(C/C=C(C)​C)​(C1=O)​C2=O InCHI Code ​1S/C38H50O6/c1-22(2)​11-13-27(25(7)​8)​20-37-21-28(15-12-23(3)​4)​36(9,10)​38(35(37)​44,18-17-24(5)​6)​34(43)​31(33(37)​42)​32(41)​26-14-16-29(39)​30(40)​19-26/h11-12,14,16-17,19,27-28,39-40,42H,7,13,15,18,20-21H2,1-6,8-10H3/t27-,28+,37+,38-/m0/s1 InCHI Key QDKLRKZQSOQWJQ-SMDXAGPFSA-N -20°C