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AB5861   MELANIN CONC HORM RCPT2, CHKX-100UG   品牌 Millipore

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MELANIN CONC HORM RCPT2, CHKX-100UG

货号： AB5861      产品名称： MELANIN CONC HORM RCPT2, CHKX-100UG   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-Melanin Concentrating Hormone Receptor Type 2 Antibody, intracellular, CT
Species Reactivity Key Applications Host Format Antibody Type
H, M, R  IHC Chicken Affinity Purified Polyclonal Antibody
Description:
Anti-Melanin Concentrating Hormone Receptor Type 2 Antibody, intracellular, CT
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Trade Name:
Chemicon (Millipore)
Specificity:
Human Melanin Concentrating Hormone Receptor Type 2 (MCH-R2). The antibody has been used to stain tissues from rat and mouse as well as human.
Epitope:
intracellular, C-terminus
Immunogen:
Synthetic 16 amino acid peptide corresponding to the intracellular carboxy-terminus of human MHC-R2.
Background Information:
Melanin Concentrating Hormone Receptor type 2 (MCH-R2) is a G-protein coupled receptor with seven transmembrane domains. MCH-R2 is 340 amino acids in length (approximately 39 kDa) and shares approximately 38% amino acid identity with MCH-R1. Like MCH-R1, it binds MCH with high affinity. However, reports indicate that signaling through this receptor is pertussis insensitive, contrary to MCH-R1. Expression of MCH-R2 mRNA is restricted to several regions of the brain, including the arcuate nucleus and the ventral medial hypothalamous (Sailer, 2001).
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Species Reactivity:
Human
Mouse
Rat
Application Notes:
Immunohistochemistry: 1 μg/mL on brain cryostat sections. The antibody stains extensively through the brain and is particularly striking in the ganglionic layer of the cerebellum.
Optimal working dilutions must be determined by end user.
Presentation:
Affinity purified immunoglobulin in PBS, pH 7.2 containing 0.1% sodium azide.
Storage Conditions:
Maintain frozen at -20°C in undiluted aliquots for up to 6 months after date of receipt. The antibody can also be diluted 1:1 with glycerol (ACS grade or better) for added stability. Avoid repeated freeze/thaw cycles.
UniProt Number:
Q969V1
Entrez Gene Number:
NM_001040179.1
NM_032503.2
Gene Symbol:
MCHR2
MCH-2R
S643b
MCH2
MCHR-2
OTTHUMP00000043201
SLT
GPR145
GPRv17
MCH2R
MCH-R2
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Alternate Names:
MCH-R2
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunohistochemistry
UniProt Summary:
FUNCTION: SwissProt: Q969V1 # Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.
SIZE: 340 amino acids; 38849 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Specifically expressed in the brain, with highest levels in cerebral cortex, hippocampus and amygdala. No expression detected in the cerebellum, thalamus or hypothalamus.
SIMILARITY: SwissProt: Q969V1 ## Belongs to the G-protein coupled receptor 1 family.
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Brand Family:
Chemicon
Product Name:
Anti-Melanin Concentrating Hormone Receptor Type 2 Antibody, intracellular, CT
Concentration:
Please refer to the Certificate of Analysis for the lot-specific concentration.
Antibody Type:
Polyclonal Antibody
Qty/Pk:
100 µg
Format:
Affinity Purified
-20℃