ANTI-RAC1 – ML

货号： 09-271ML-KL      产品名称： ANTI-RAC1 – ML   品牌： Millipore 规格： ML 三周到货 生化实验

Anti-Rac1b
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REFERENCES
Ibuprofen inhibits colitis-induced overexpression of tumor-related rac1b.
Matos, Paulo, et al. (2013) Neoplasia, 15: 102-11 (2013)
Involvement of hnRNP A1 in the matrix metalloprotease-3-dependent regulation of Rac1 pre-mRNA splicing.
Federico Pelisch,Davitte Khauv,Guillermo Risso,Melody Stallings-Mann,Matías Blaustein,Leandro Quadrana,Derek C Radisky,Anabella Srebrow (2012) Journal of cellular biochemistry.113
Rac1b regulates NT3-stimulated Mek-Erk signaling, directing marrow-isolated adult multilineage inducible (MIAMI) cells toward an early neuronal phenotype.
Kevin M Curtis,Lourdes A Gomez,Paul C Schiller (2012) Molecular and cellular neurosciences.49
Species Reactivity Key Applications Host Format Antibody Type
H, M  WB, IH(P), IF Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-Rac1b Antibody
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes Rac1b specifically. Does not recognize other Rac1 isoforms.
Molecular Weight:
22 kDa
Immunogen:
Synthetic peptide consisting of the internal region of Rac1b that is not in the other Rac1 isoforms.
Background Information:
Rac is a member of the Rho family of small GTP-binding proteins. It plays roles in cytoskeletal actin organization as well as transformation along with its other Rho family members. Rac, Rho, and Cdc42 all work in concert with one another in the assembly of actin-based structures such as lamellipodia, stress fibers, and filopodia, respectively to control cell migration. Rac is activated downstream of cdc42, or independently by Ras signaling, and in turn Rac stimulates Rho. Effectors of the Rac pathway include NADPH Oxidase and the SAPK1/JNK family of kinases. The latter pathway is activated by the PAK kinases, which are direct targets of Rac.
Rac1b is a highly active splice varient of Rac1. It differs in that it has an additional 19 amino acids. It has been found in various tumors such as breasts and colorectal.
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Species Reactivity:
Human
Mouse
Quality Assurance:
routinely evaluated by western blot on MCF7 cell lysate
Purification Method:
Affinity Purfied
Presentation:
Purified rabbit polyclonal IgG in storage buffer containing PBS with 0.07% sodium azide in 30% glycerol.
Storage Conditions:
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
UniProt Number:
P63000
Entrez Gene Number:
NP_061485.1
Gene Symbol:
RAC1
MGC111543
ORFNames=MIG5
PAK1
MIG5
TC-25
p21-Rac1
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Immunohistochemistry (Paraffin)
Immunofluorescence
Entrez Gene Summary:
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, inc -20℃