Anti-phospho-Rb (Ser807/Ser811)

货号： ABC132      产品名称： Anti-phospho-Rb (Ser807/Ser811)   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-phospho-Rb (Ser807/Ser811)
Close
PRODUCT FAMILY INFORMATION
Rb (Retinoblastoma) Antibodies, Proteins and Kits
Millipore’s Rb Antibodies demonstrate specificity against Retinoblastoma (also known as p105, p110 or pRb). See below related products for Rb, based on the expertise of Upstate & Chemicon.
Millipore’s Anti- Rb Antibodies demonstrates specificity against Rb. See below for data, references and related products for Rb. All Millipore antibodies are based on the expertise of Upstate & Chemicon.
» More…
Species Reactivity Key Applications Host Format Antibody Type
H, M  WB, Cell Function Assay Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-phospho-Rb (Ser807/Ser811) Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Specificity:
This antibody recognizes Rb phosphorylated at Ser807/Ser811.
Molecular Weight:
~110 kDa observed
Epitope:
Phosphorylated Ser807/Ser811
Immunogen:
KLH-conjugated linear peptide corresponding to human Rb phosphorylated at Ser807/Ser811.
Modifications:
Phosphorylation
Phosphorylation
Background Information:
The retinoblastoma (Rb) gene product (also known as p105, p110 or pRb) is a tumor suppressor protein that is missing or mutated in a variety of human tumors. In the hereditary childhood form of retinoblastoma, Rb is lost from chromosome 13. Rb regulates cell proliferation and differentiation by controlling progression through the restriction point within the G1 phase of the cell cycle. Rb forms complexes with many proteins, and this binding activity is required for growth suppression. Rb specifically interacts with the E2F family of transcription factors to repress E2F-mediated transcription. Rb also interacts and alters the activity of other transcription factors including Elf-1, ATF-2, MyoD, BRG-1, c-myc, N-myc. Rb recruits a histone deacetylase, HDAC1, to E2F-1 to repress transcription. Two Rb related proteins p107 and p130 also function to regulate specific members of the E2F transcription factor family.
View All »
Species Reactivity:
Human
Mouse
Species Reactivity Note:
Demonstrated to react with Human.
Predicted to react with Mouse based on 100% sequence homology. (11/12 amino acids identical in Rat and chicken Rb).
Application Notes:
Peptide Inhibition Assay Analysis: 0.05 µg/mL from a representative lot peptide blocked on MOLT4 cells stimulated with PMA.
Control:
Untreated and lambda phosphatase-treated MOLT4 cell lysates stimulated with PMA
Quality Assurance:
Evaluated by Western Blot in untreated and lambda phosphatase-treated MOLT4 cell lysates stimulated with PMA.
Western Blot Analysis: 0.05 µg/mL of this antibody detected Rb on 10 µg of untreated and lambda phosphatase-treated MOLT4 cell lysates stimulated with PMA.
View All »
Purification Method:
Affinity Purified
Presentation:
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
P06400
Entrez Gene Number:
NP_000312
Gene Symbol:
RB1
Alternate Names:
Retinoblastoma-associated protein
p105-Rb
pRb
Rb
pp110
View All »
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vi 2-8℃