Anti-GABA(A) receptor-associated pr

货号： ABC58      产品名称： Anti-GABA(A) receptor-associated pr   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-GABA(A) receptor-associated protein-like 1
Species Reactivity Key Applications Host Format Antibody Type
H, M, R, Po  WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-GABARAP/GABARAPL1 Antibody
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Specificity:
This antibody recognizes GABA(A) receptor-associated protein-like 1 at the N-terminal of Interaction with GABRG2 domain.
Molecular Weight:
~14 kDa observed
Epitope:
N-terminal of Interaction with GABRG2 domain
Immunogen:
KLH-conjugated linear peptide corresponding to human GABA(A) receptor-associated protein-like 1 at the N-terminal of Interaction with GABRG2 domain.
Background Information:
GABA(A) receptor-associated protein-like 1 (GABRAPL1) is a ubiquitin-like modifier with a ubiquitin-like fold that targets lipid membranes instead of proteins. GABA(A) receptor-associated protein-like 1 increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Studies implicate a relationship between the expression of GABA(A) protein-like 1 to cellular growth and breast adenocarcinoma and that level of GABRAPL1 mRNA expression in breast tumor may be a good indicator of the risk of recurrence.
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Species Reactivity:
Human
Mouse
Rat
Pig
Species Reactivity Note:
Demonstrated to react with Human, Mouse, and Rat. Predicted to react with Porcine based on 100% sequence homology.
Control:
Raji cell lysate
Quality Assurance:
Evaluated by Western Blot in Raji cell lysate.
Western Blot Analysis: 0.05 µg/mL of this antibody detected GABA(A) receptor-associated protein-like 1 on 10 µg of Raji cell lysate.
Purification Method:
Affinity purified
Presentation:
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
Q9H0R8
Entrez Gene Number:
NP_113600
Gene Symbol:
GABARAPL1
GEC1
Alternate Names:
Gamma-aminobutyric acid receptor-associated protein-like 1
Early estrogen-regulated protein
GABA(A) receptor-associated protein-like 1
Glandular epithelial cell protein 1
GEC-1
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
UniProt Summary:
FUNCTION: Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor.
SUBUNIT STRUCTURE: Interacts with GABRG2 and beta-tubulin (By similarity). Interacts with OPRK1.
SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton. Membrane (By similarity). Endoplasmic reticulum (By similarity). Golgi apparatus (By similarity).
TISSUE SPECIFICITY: Ubiquitous. Expressed at very high levels in the brain, heart, peripheral blood leukocytes, liver, kidney, placenta and skeletal muscle. Expressed at very low levels in thymus and small intestine.
SEQUENCE SIMILARITIES: Belongs to the MAP1 LC3 family.
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Product Name:
Anti-GABA(A) receptor-associated protein-like 1
Concentration:
2-8℃