Anti-Neurexin3

货号： ABN96      产品名称： Anti-Neurexin3   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-Neurexin3
Species Reactivity Key Applications Host Format Antibody Type
H, M, R  WB, IHC Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-Neurexin3 Antibody
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Molecular Weight:
~180 kDa observed. UniProtKB/Swiss-Prot Q9Y4C0 (NRX3A_HUMAN) states 2 isoforms due to alternative promoter usage and alternative splicing at a molecular weight of ~181 kDa and ~117 kDa, with several beta isoforms at a molecular weight 70 kDa, 51 kDa, 47 kDa, and 44 kDa. Additional bands may also be observed around 40-55 kDa as a possible result of the posttranslational processing.
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Immunogen:
KLH-conjugated linear peptide corresponding to human Neurexin-3.
Background Information:
Neurexins are heavily glycosylated and processed neuronal transmembrane cell surface proteins likely involved in cell recognition and adhesion. (Missler, M., et al. (1998) 14(1):20-26) Antibody Anti-neurexin 3 alpha (ABN96) was made against a peptide immunogen corresponding to a stretch of amino acids in the extracellular domain of human neurexin 3 alpha (Uniprot Q9Y4C0). Although the theoretical full length of Neurexin 1alpha is 180 kDa, the protein detected in human brain lysates may show a band around 180 kDa and additional bands around 40-55 kDa as a possible result of the posttranslational processing previously reported. The Immunohistochemical staining using ABN35 localizes this protein to neuronal cytoplasm also consistent with previous research. (Dean, C., et al., (2003). 6(7):708-716.)
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Species Reactivity:
Human
Mouse
Rat
Species Reactivity Note:
Demonstrated to react with Human, Mouse, and Rat.
Application Notes:
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Neurexin-3 in normal mouse brain tissue.
Control:
PC12 cell lysate.
Quality Assurance:
Evaluated by Western Blot in PC12 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Neurexin-3 in 10 µg of PC12 cell lysate.
Purification Method:
Affinity purified
Presentation:
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
Q9Y4C0
Entrez Gene Number:
NP_004787
Gene Symbol:
NRXN3
C14orf60
KIAA0743
Alternate Names:
Neurexin-3-alpha
Neurexin III-alpha
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Immunohistochemistry
Entrez Gene Summary:
Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The al 2-8℃