Anti-phospho-mTOR (Ser2159)

货号： ABS79      产品名称： Anti-phospho-mTOR (Ser2159)   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-phospho-mTOR (Ser2159)
Species Reactivity Key Applications Host Format Antibody Type
H, M, R, Sh, Zebrafish  WB, PIA, DB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-phospho-mTOR (Ser2159) Antibody
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Specificity:
This antibody recognizes mTOR phosphorylated at Ser2159.
Molecular Weight:
290 kDa calculated
Epitope:
Phosphorylated at Ser2159
Immunogen:
KLH-conjugated linear peptide corresponding to human mTOR phosphorylated at Ser2159.
Background Information:
The mammalian target of rapamycin (mTOR), also known as FRAP, RAFT, or RAPT, is a ubiquitously expressed serine/threonine kinase that belongs to the phosphoinositide 3-kinase–related kinase (PIKK) family. mTOR functions as a downstream effector in the PI3K pathway and is activated by the Akt kinase. mTOR responds to signals from growth factors and promotes protein synthesis underlying cell proliferation, by activation of the S6 kinase and inhibition of the 4E-BP protein involved in protein translation. Several studies have suggested that the proliferative functions of mTOR may contribute to the development of cancer.
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Species Reactivity:
Human
Mouse
Rat
Sheep
Zebrafish
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Species Reactivity Note:
Demonstrated to react with Human. Predicted to react with Mouse, Rat, Zebra Fish, and Sheep based on 100% sequence homology.
Application Notes:
Western Blot Analysis: A representative lot detected phospho-mTOR (Ser2159) in HEK293 cell lysate. Image courtesy from the laboratory of Dr. Diane Fingar, University of Michigan Medical School.
Control:
Unmodified and modified mTOR peptides
Quality Assurance:
Evaluated by Dot Blot in unmodified and modified mTOR peptides.
Dot Blot Specificity Analysis: Unmodified and modified mTOR peptides (see Table) were probed with Anti-phospho-mTOR (Ser2159) (1:1,000 dilution).
Purification Method:
Affinity purified
Presentation:
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
P42345
Entrez Gene Number:
NP_004949
Gene Symbol:
MTOR
FRAP
FRAP1
FRAP2
RAFT1
RAPT1
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Alternate Names:
Serine/threonine-protein kinase mTOR
FK506-binding protein 12-rapamycin complex-associated protein 1
FKBP12-rapamycin complex-associated protein
Mammalian target of rapamycin
mTOR
Mechanistic target of rapamycin
Rapamycin and FKBP12 target 1
Rapamycin target protein 1
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Peptide Inhibition Assay
Dot Blot
Product Name:
Anti-phospho-mTOR (Ser2159)
Concentration:
Please refer to the Certificate of Analysis for the lot-specific concentration.
Antibody Type:
Polyclonal Antibody
Qty/Pk:
100 µL
Format:
Affinity Purified
Host:
Rabbit
Applications:
Anti-phospho-mTOR (Ser2159) Antibody detects level of phos 2-8℃