Anti-SHIP

货号： ABS10      产品名称： Anti-SHIP   品牌： Millipore 规格： *** 三周到货 生化实验

Anti-SHIP
Species Reactivity Key Applications Host Format Antibody Type
H  WB, IP Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-SHIP Antibody
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Specificity:
This antibody recognizes SHIP at the C-terminus.
Molecular Weight:
~145 kDa observed
Epitope:
C-terminus
Immunogen:
GST-tagged recombinant protein corresponding to the C-terminus of human SHIP.
Background Information:
Expressed only in hematopoietic cells, Src homology (SH)-2 containing Inositol phosphatase (SHIP) is a member of the Inositol polyphosphatase-5-phosphatase (INPP5) family characterized as containing several protein interaction domains that include an Inositol phosphatase domain, a SH2 domain, and a proline-rich domain. SHIP hydrolyzes the phosphatidylinositol 3-kinase product phosphatidylinositol-3,4,5-triphosphatase, a requirement of activation for several enzymes containing pleckstrin homology domains. The movement of this protein from cytosol to the plasma membrane is regulated by tyrosine phosphorylation as a response to various activations by cytokines and T and B cell receptors. SHIP is a necessary negative regulator, moderating the balance of both the positive and negative signals in myeloid cells and lymphocytes. There are multiple forms of SHIP, which have been shown to result from the truncation of the C-terminus.
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Species Reactivity:
Human
Species Reactivity Note:
Demonstrated to react with Human.
Application Notes:
Immunoprecipitation Analysis: 10 µg of this antibody immunoprecipitated SHIP protein from Ramos lysate.
Control:
TF-1 cell lysate
Quality Assurance:
Evaluated by Western Blot in TF-1 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected SHIP on 10 µg of TF-1 cell lysate.
Purification Method:
Affinity purified
Presentation:
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
Q92835
Entrez Gene Number:
NP_001017915
Gene Symbol:
INPP5D
hp51CN
p150Ship
SHIP
SIP-145
SHIP-1
SHIP1
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Alternate Names:
inositol polyphosphate-5-phosphatase, 145kDa
SH2 containing inositol phosphatase
signaling inositol polyphosphate 5 phosphatase SIP-145
Inositol polyphosphate-5-phosphatase of 145 kDa
inositol polyphosphate-5-phosphatase, 145kD
SH2 domain-containing inositol phosphatase 1
SH2 containing inositol phosphatase, isoform b
SH2 domain-containing inositol-5′-phosphatase 1
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Immunoprecipitation
Entrez Gene Summary:
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At 2-8℃