Anti-SHIP, clone P1C1

货号： 05-1911      产品名称： Anti-SHIP, clone P1C1   品牌： Millipore 规格： EA 3周到货 生化实验

Anti-SHIP Antibody, clone P1C1
Description:
Anti-SHIP Antibody, clone P1C1
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Specificity:
This antibody recognizes SHIP.
Molecular Weight:
145 kDa observed. Doublet expected at higher antibody concentrations.
Epitope:
Unknown
Immunogen:
KLH-conjugated linear peptide corresponding to human SHIP.
Clone:
P1C1
Isotype:
IgG1κ
Background Information:
Expressed only in hematopoietic cells, Src homology (SH)-2 containing Inositol phosphatase (SHIP) is a member of the Inositol polyphosphatase-5-phosphatase (INPP5) family characterized as containing several protein interaction domains that include an Inositol phosphatase domain, a SH2 domain, and a proline-rich domain. SHIP hydrolyzes the phosphatidylinositol 3-kinase product phosphatidylinositol-3,4,5-triphosphatase, a requirement of activation for several enzymes containing pleckstrin homology domains. The movement of this protein from cytosol to the plasma membrane is regulated by tyrosine phosphorylation as a response to various activations by cytokines and T and B cell receptors. SHIP is a necessary negative regulator, moderating the balance of both the positive and negative signals in myeloid cells and lymphocytes. There are multiple forms of SHIP, which have been shown to result from the truncation of the C-terminus.
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Species Reactivity:
Human
Mouse
Species Reactivity Note:
Demonstrated to react with human. Predicted to react with mouse based on 100% sequence homology.
Application Notes:
Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP. (Lucas, D., et al. (1999). Blood. 93(6):1922-1933.)
Control:
THP-1 cell lysate
Quality Assurance:
Evaluated by Western Blot in THP-1 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected SHIP on 10 µg of THP-1 cell lysate.
Purification Method:
Protein G purfied
Presentation:
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
Q92835
Entrez Gene Number:
NP_001017915.1
Gene Symbol:
INPP5D
hp51CN
p150Ship
SHIP
SIP-145
SHIP-1
SHIP1
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Alternate Names:
inositol polyphosphate-5-phosphatase, 145kDa
SH2 containing inositol phosphatase
signaling inositol polyphosphate 5 phosphatase SIP-145
Inositol polyphosphate-5-phosphatase of 145 kDa
inositol polyphosphate-5-phosphatase, 145kD
SH2 domain-containing inositol phosphatase 1
SH2 containing inositol phosphatase, isoform b
SH2 domain-containing inositol-5′-phosphatase 1
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Immunocytochemistry
Immunoprecipitation
Entrez Gene Summary:
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement 2°C – 8°C