a-M-Cadherin, clone 12G4 100ug

货号： 05-852      产品名称： a-M-Cadherin, clone 12G4 100ug   品牌： Millipore 规格： EA 3周到货 生化实验

Anti-M-Cadherin Antibody, clone 12G4
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REFERENCES
Structure-based models of cadherin-mediated cell adhesion: the evolution continues.
Koch, A W, et al. (2004) Cell. Mol. Life Sci., 61: 1884-95 (2004)
The cadherin-catenin complex as a focal point of cell adhesion and signalling: new insights from three-dimensional structures.
Gooding, Jane M, et al. (2004) Bioessays, 26: 497-511 (2004)
Convergence of Wnt, beta-catenin, and cadherin pathways.
Nelson, W James and Nusse, Roel (2004) Science, 303: 1483-7 (2004)
M-cadherin and its sisters in development of striated muscle.
Kaufmann, U, et al. (1999) Cell Tissue Res., 296: 191-8 (1999)
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Species Reactivity Key Applications Host Format Antibody Type
M  ELISA, WB, ICC Mouse Purified Monoclonal Antibody
Description:
Anti-M-Cadherin Antibody, clone 12G4
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Trade Name:
Upstate (Millipore)
Specificity:
M-Cadherin
Molecular Weight:
Mr 130kDa
Immunogen:
Recombinant extracellular domain of mouse M-Cadherin
Isotype:
IgG1κ
Species Reactivity:
Mouse
Species Reactivity Note:
Does NOT cross react with Human
Quality Assurance:
routinely evaluated by immunoblot on modified RIPA lysates from C2C12 cells
Purification Method:
Thiophilic adsorption and size exclusion
Storage Conditions:
Stable for 1 year at -20°C from date of shipment
UniProt Number:
P55291
Entrez Gene Number:
NM_007662
Gene Symbol:
CDH15
CDH3
myotubule-cadherin
cadherin-14
Muscle-cadherin
CDHM
cadherin-3
muscle-cadherin
Cadherin-14
M-cadherin
CDH14
MCAD
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
ELISA
Western Blotting
Immunocytochemistry
Entrez Gene Summary:
This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation.
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UniProt Summary:
FUNCTION: SwissProt: P55291 # Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.
SIZE: 814 amino acids; 88916 Da
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P55291 ## Contains 5 cadherin domains.
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Brand Family:
Upstate
Product Name:
Anti-M-Cadherin Antibody, clone 12G4
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 µg
Format:
Purified
Host:
Mo -20°C