A-ACET-HIST H4(K8), CHIP GRD 100UL

货号： 07-328      产品名称： A-ACET-HIST H4(K8), CHIP GRD 100UL   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-acetyl-Histone H4 (Lys8) Antibody
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REFERENCES
Role of histone acetylation in the stimulatory effect of valproic acid on vascular endothelial tissue-type plasminogen activator expression.
Pia Larsson,Erik Ulfhammer,Mia Magnusson,Niklas Bergh,Sebastian Lunke,Assam El-Osta,Robert L Medcalf,Per-Arne Svensson,Lena Karlsson,Sverker Jern (2012) PloS one.7
Analysis of model replication origins in Drosophila reveals new aspects of the chromatin landscape and its relationship to origin activity and the pre-RC.
Liu J, McConnell K, Dixon M, Calvi BR (2011) Molecular biology of the cell
Hasegawa Y, Takahashi N, Forrest AR, Shin JW, Kinoshita Y, Suzuki H, Hayashizaki Y (2011) Stem cells (Dayton, Ohio)
Domains of Tra1 important for activator recruitment and transcription coactivator functions of SAGA and NuA4 complexes.
Knutson BA, Hahn S (2011) Mol Cell Biol.31:818-31. Epub 2010 Dec 13.
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Species Reactivity Key Applications Host Format Antibody Type
H, Yeast (S. cerevisiae)  IP, WB, DB, ChIP-seq Rabbit Serum Polyclonal Antibody
Description:
Anti-acetyl-Histone H4 (Lys8) Antibody
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes acetyl-Histone H4 (Lys8).
Molecular Weight:
10 kDa
Immunogen:
Peptide corresponding to amino acids 3-13 of yeast Histone H4 (RGKGGAcKGLGKG-C) in which lysine 8 is acetylated.
Modifications:
Acetylation
Isotype:
IgG
Background Information:
Histone H4 is one of the 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N terminal tail H4 is involved with the structure of the nucleosomes of the ‘beads on a string’ structure.
The N-terminal tail of histone H4 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
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Species Reactivity:
Human
Yeast (S. cerevisiae)
Control:
Sodium butyrate treated HeLa cells
Quality Assurance:
routinely evaluated by immunoblot on acid extracts from sodium butyrate treated HeLa cells
Purification Method:
Unpurified
Presentation:
Unpurified rabbit polyclonal in serum with 0.05% sodium azide.
Storage Conditions:
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
UniProt Number:
P62805
Entrez Gene Number:
NM_175054
Gene Symbol:
HIST1H4A
H4/J
HIST1H4F
HIST1H4L
H4FN
H4FA
H4FH
HIST1H4H
H4F2
H4FM
H4/A
H4FK
H4FG
HIST2H4
H4FB
H4/K
HIST1H4I
H4/N
HIST1H4B
H4FE
H4/M
H4/a
HIST1H4E
HIST4H4
HIST2H4A
H4FC
H4FI
H4/H
HIST1H4C
H4/G
HIST1H4K
H4FJ
H4FD
H4/I
H4/B
H4/D
H4/C
HIST1H4J
HIST1H4D
H4/E
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Alternate Names:
H4K8Ac
Histone H4 (acetyl K8)
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unaut -20℃