标签： trkc

ANTI-TRKC 200UG

货号： 07-226      产品名称： ANTI-TRKC 200UG   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-TrkC Antibody
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REFERENCES
Overexpression of miR-128 specifically inhibits the truncated isoform of NTRK3 and upregulates BCL2 in SH-SY5Y neuroblastoma cells.
Monica Guidi,Margarita Muiños-Gimeno,Birgit Kagerbauer,Eulàlia Martí,Xavier Estivill,Yolanda Espinosa-Parrilla (2010) BMC molecular biology.11
Expression of Trk receptors in the developing mouse trigeminal ganglion: in vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkC.
Huang, E J, et al. (1999) Development, 126: 2191-203 (1999)
Species Reactivity Key Applications Host Format Antibody Type
H, M, R  WB Goat Purified Polyclonal Antibody
Description:
Anti-TrkC Antibody
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Trade Name:
Upstate (Millipore)
Molecular Weight:
145kDa
Immunogen:
Extracellular domain of rat TrkC receptor, corresponding to amino acid residues 1-429
Isotype:
IgG
Species Reactivity:
Human
Mouse
Rat
Purification Method:
Protein G chromatography
UniProt Number:
Q16288
Entrez Gene Number:
NM_019248
Gene Symbol:
NTRK3
TRKC
Trk-C
gp145(trkC)
GP145-TrkC
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.
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UniProt Summary:
FUNCTION: SwissProt: Q16288 # Receptor for neurotrophin-3 (NT-3). This is a tyrosine- protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
SIZE: 839 amino acids; 94428 Da
SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain.
PTM: Ligand-mediated auto-phosphorylation.
SIMILARITY: SwissProt: Q16288 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 2 LRR (leucine-rich) repeats. & Contains 1 protein kinase domain.
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Brand Family:
Upstate
Product Name:
Anti-TrkC Antibody
Antibody Type:
Polyclonal Antibody
Qty/Pk:
200 µg
Format:
Purified
Host:
Goat
Applications:
Detect TrkC using this Anti-TrkC Antibody validated for use in WB.