标签： gpcr

371825-10MG   GPCR-Helix 8 Signaling Inhibitor, JF5   品牌 Merck

GPCR-Helix 8 Signaling Inhibitor, JF5

货号： 371825-10MG      产品名称： GPCR-Helix 8 Signaling Inhibitor, JF5   品牌： Merck 规格： *** 3周到货 生化实验

GPCR-Helix 8 Signaling Inhibitor, JF5
A cell-permeable quinolinimine compound that acts as a selective, potent blocker of G-protein coupled receptors (GPCR) that contain a constrained eighth helix (H8). The inhibition is selective and blocks G-protein signaling mediated via Gαq, but not Gα12. A non-orthosteric antagonist of PAR1 (IC50 = 4 µM) that is shown to inhibit PAR1 and CCR-4 induced platelet aggregation without affecting PAR4 mediated aggregation. Shown to inhibit thrombus formation following vascular injury (IC50 ~1 mg/kg). Also acts as a potent, non-competitive blocker of α2A-adrenergic receptors (IC50 = 2.5 µM as shown by a decrease in 3H-yohimbine binding).
产品信息
Form  Off-white powder
Molar mass  382.3
Protect from Light  是的
Hygrocopic  是的
Packaged under inert gas  是的
Purity  ≥92% by HPLC
Solubility  DMSO
Chemical formula  C17H22N2 • HI
商店和运输信息
Storage  +2°C to +8°C
Ship  Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling

2°C – 8°C

4367785   TLDA HUMAN GPCR PANEL, TOPFILL   品牌 Invitrogen

TLDA HUMAN GPCR PANEL, TOPFILL

货号： 4367785      产品名称： TLDA HUMAN GPCR PANEL, TOPFILL   品牌： Invitrogen 规格： EACH 三周到货 生化试验

TaqMan® Array Human GPCR Panel
The Applied Biosystems® TaqMan® Human GPCR Array is an efficient, easy-to-use micro fluidic card for quantitative gene expression analysis of human GPCR genes important in drug discovery. This product is designed with 380 TaqMan® Gene Expression Assays arrayed in singletons in 384 wells (plus 1 control arrayed in quadruplicate) and is compatible with an upgraded Applied Biosystems 7900HT Fast Real-Time PCR System. The targets include olfactory receptors, retinal receptors, small molecule receptors, chemokine receptors and others including classic endogenous markers. This product is sold in packages of 4 cards.
Form: Dried Down
Format: 384-well microfluidic card 
Species: Human 
Target Gene: 50 GPCR subfamilies (excludes odorant, olfactory, gustatory and pheromone receptors) 
Label or Dye: FAM™ 
Product Size: 4 cards 
Reaction Speed: Standard 
Research Category: Biomarker-Related Pathway(s),
Toxicology & Drug Metabolism,
Extracellular Matrix & Cell Adhesion,
Immunology,
Apoptosis,
Neurobiology,
Signal Transduction,
Oncology,
Development,
Reproduction,
Cell Cycle & Proliferation 
Internal Probe Modification: Non-Fluorescent Quencher (3′),
MGB (Minor Groove Binder) (3′),
FAM (5′) 
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Each TaqMan® Array well contains a single TaqMan® Assay for one 2 µL reaction. The cards should be stored at 4°C.

4378703   TF, TLDA MOUSE GPCR PANEL   品牌 Invitrogen

TF, TLDA MOUSE GPCR PANEL

货号： 4378703      产品名称： TF, TLDA MOUSE GPCR PANEL   品牌： Invitrogen 规格： EACH 三周到货 生化试验

TaqMan® Array Mouse GPCR Panel
The Applied Biosystems® TaqMan® Mouse GPCR Array is an efficient, easy-to-use micro fluidic card for quantitative gene expression analysis of mouse GPCR genes important in drug discovery. This product is designed with 380 TaqMan® Gene Expression Assays arrayed in singletons in 384 wells (plus 1 control arrayed in quadruplicate) and is compatible with an upgraded Applied Biosystems 7900HT Fast Real-Time PCR System. The targets include retinal receptors, small molecule receptors, chemokine receptors and others including classic endogenous control targets. This product is packaged in 1 box containing 4 cards.
The GPCR targets selected fall into the 50 subfamilies listed, many of which are drug targets or disease associated. Odorant, olfactory, gustatory or pheromone receptors are not included on these arrays. The array is pre-formatted and inventoried, cost-effective, convenient and easy to use without needing expensive robotics. Results are reproducible and consistent across samples, studies, and labs —the same data quality from card-to-card and lot-to-lot — even with different operators.
Form: Dried Down 
Format: 384-well microfluidic card 
Species: Mouse
Target Gene: 50 GPCR subfamilies (excludes odorant, olfactory, gustatory and pheromone receptors)
Label or Dye: FAM™ 
Product Size: 4 cards 
Reaction Speed: Standard 
Research Category: Biomarker-Related Pathway(s),
Toxicology & Drug Metabolism,
Extracellular Matrix & Cell Adhesion,
Immunology,
Apoptosis,
Neurobiology,
Signal Transduction,
Oncology,
Development,
Reproduction,
Cell Cycle & Proliferation 
Internal Probe Modification: FAM (5′),
MGB (Minor Groove Binder) (3′),
Non-Fluorescent Quencher (3′) 
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Each TaqMan® Array well contains a single TaqMan® Assay for one 2 µL reaction. The cards should be stored at 4°C.

4378709   TF, TLDA RAT GPCR PANEL   品牌 Invitrogen

TF, TLDA RAT GPCR PANEL

货号： 4378709      产品名称： TF, TLDA RAT GPCR PANEL   品牌： Invitrogen 规格： EACH 三周到货 生化试验

TaqMan® Array Rat GPCR Panel
The Applied Biosystems® TaqMan® Mouse GPCR Array is an efficient, easy-to-use micro fluidic card for quantitative gene expression analysis of mouse GPCR The TaqMan® Rat GPCR Array is an efficient, easy-to-use micro fluidic card for quantitative gene expression analysis of rat GPCR genes important in drug discovery. This product is designed with 380 TaqMan® Gene Expression Assays arrayed in singletons in 384 wells (plus 1 control arrayed in quadruplicate) and is compatible with an upgraded Applied Biosystems 7900HT Fast Real-Time PCR System. The targets include retinal receptors, small molecule receptors, chemokine receptors and others including classic endogenous control targets. GPCR Panels are sold in packs of 4.
The GPCR targets selected fall into the 50 subfamilies listed, many of which are drug targets or disease associated —odorant, olfactory, gustatory or pheromone receptors are not included. The array is pre-formatted and inventoried, cost-effective, convenient and easy to use without needing expensive robotics. Results are reproducible and consistent across samples, studies, and labs —the same data quality from card-to-card and lot-to-lot — even with different operators.
Form: Dried Down 
Format: 384-well microfluidic card 
Species: Rat 
Target Gene: 50 GPCR subfamilies (excludes odorant, olfactory, gustatory and pheromone receptors) 
Label or Dye: FAM™ 
Product Size: 4 cards 
Reaction Speed: Standard
Research Category: Biomarker-Related Pathway(s),
Toxicology & Drug Metabolism,
Extracellular Matrix & Cell Adhesion,
Immunology,
Apoptosis,
Neurobiology,
Signal Transduction,
Oncology,
Development,
Reproduction,
Cell Cycle & Proliferation 
Internal Probe Modification: FAM (5′),
MGB (Minor Groove Binder) (3′),
Non-Fluorescent Quencher (3′) 
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Each TaqMan® Array well contains a single TaqMan® Assay for one 2 µL reaction. The cards should be stored at 4°C.

4414137   HUMAN GPCR PATHWAY   品牌 Invitrogen

HUMAN GPCR PATHWAY

货号： 4414137      产品名称： HUMAN GPCR PATHWAY   品牌： Invitrogen 规格： EACH 三周到货 生化试验

TaqMan® Array Human GPCR Pathway
These 96-well plates are pre-configured with the most appropriate TaqMan® Gene Expression Assays for a specific biological process, pathway, or disease state. Each plate contains predefined assays and endogenous controls dried-down in the wells, ready for accurate assessment of an entire gene signature in one simple experiment. The TaqMan® Array Human GPCR Pathway 96-well Plate contains 92 assays to genes associated with GPCR pathways and 4 assays to candidate endogenous control genes.
Form: Dried Down 
Format: 96-well plate
Species: Human
Label or Dye: FAM™ 
Product Size: 1 standard plate 
Reaction Speed: Standard 
Research Category: Oncology,
Apoptosis,
Biomarker-Related Pathway(s),
Development,
Immunology,
Signal Transduction 
Internal Probe Modification: Non-Fluorescent Quencher (3′),
MGB (Minor Groove Binder) (3′),
FAM (5′) 
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Each TaqMan® Array Plate well contains a single TaqMan® Assay for one 20 µL reaction. The plates can be stored at room temperature or at 4°C.

4418782   HS GPCR PATHWAY, FAST   品牌 Invitrogen

HS GPCR PATHWAY, FAST

货号： 4418782      产品名称： HS GPCR PATHWAY, FAST   品牌： Invitrogen 规格： EACH 三周到货 生化试验

TaqMan® Array, Human GPCR Pathway, Fast 96-well
These 96-well plates are pre-configured with the most appropriate TaqMan® Gene Expression Assays for a specific biological process, pathway, or disease state. Each plate contains predefined assays and endogenous controls dried-down in the wells, ready for accurate assessment of an entire gene signature in one simple experiment. The TaqMan® Array Human GPCR Pathway 96-well Plate contains 92 assays to genes associated with GPCR pathways and 4 assays to candidate endogenous control genes.
Form: Dried Down 
Format: 96-well plate 
Species: Human 
Label or Dye: FAM™ 
Product Size: 1 x 96 well plate 
Reaction Speed: Fast 
Research Category: Signal Transduction,
Apoptosis,
Immunology,
Biomarker-Related Pathway(s),
Neurobiology 
Internal Probe Modification: Non-Fluorescent Quencher (3′),
MGB (Minor Groove Binder) (3′),
FAM (5′)
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Each TaqMan® Array Plate well contains a single TaqMan® Assay for one 10 µL reaction. The plates can be stored at room temperature or at 4°C.