Anti-BMPR-1A
货号： ABD51 产品名称： Anti-BMPR-1A 品牌： Millipore 规格： EA 三周到货 生化实验
Anti-BMPR-1A
Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-BMPR-1A Antibody
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Specificity:
This antibody recognizes BMPR-1A at the extracellular domain.
Molecular Weight:
~75 kDa observed. The calculated molecular weight is 67 kDa; however, BMPR-1A has been shown as a ~77 kDa band in western blots (Koenig, B., et al. (1994). Molecular and Cellular Biology. 14(9):5961-5974).
Epitope:
Extracellular domain
Immunogen:
KLH-conjugated linear peptide corresponding to the extracellular domain of human BMPR-1A.
Background Information:
BMPR-1A (bone morphogenic protein receptor type 1A) signaling is known to be important for inner root sheath differentiation, hair follicle cycling and tooth development. Mutations in BMPR-1A are a common cause of juvenile polyposis syndrome (JPS). BMPR-1A is expressed in a high quantity during the formation of the primary and secondary palate and the loss of BMPR-1A could be a cause for the cleft palate birth defect.
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Species Reactivity:
Human
Mouse
Rat
Control:
NIH/3T3 cell lysate
Quality Assurance:
Evaluated by Western Blot in NIH/3T3 cell lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected BMPR-1A on 10 µg of NIH/3T3 cell lysate.
Purification Method:
Affinity purified
Presentation:
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
P36894
Entrez Gene Number:
NP_004320
Gene Symbol:
BMPR1A
ACVRLK3
ALK3
Alternate Names:
Bone morphogenetic protein receptor type-1A
BMP type-1A receptor
BMPR-1A
Activin receptor-like kinase 3
ALK-3
Serine/threonine-protein kinase receptor R5
SKR5
CD_antigen=CD292
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq].
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UniProt Summary:
FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators 2-8℃
