Anti-AXL

货号： ABN275      产品名称： Anti-AXL   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-AXL Antibody
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Species Reactivity Key Applications Host Format Antibody Type
H  WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-AXL Antibody
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Molecular Weight:
~140 kDa observed. The calculated molecular weight of this protein is 98 kDa, but is observed at ~140 kDa which is considered to represent the auto-phosphorylated endogenous form. (Collett, G., et al. (2003). Circ Res. 92(10):1123-1129.)
Immunogen:
GST-tagged recombinant protein corresponding to human AXL.
Background Information:
Tyrosine-protein kinase receptor UFO (AXL) is a member of the Tyr protein kinase family. It is a single-pass type I membrane protein containing two fibronectin type-III domains, two Ig-like C2-type domains and one protein kinase domain. AXL mRNA is widely expressed with the highest levels in the heart and skeletal muscle. Gas6/AXL signaling plays a role in cell survival, cell proliferation, migration and differentiation. Mutations in AXL have been assoicated with thyroid carcinoma and many other cancers.
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Species Reactivity:
Human
Species Reactivity Note:
Demonstrated to react with Human.
Control:
HepG2 cell lysate
Quality Assurance:
Evaluated by Western Blotting in HepG2 cell lysate.
Western Blotting Analysis: A 1:1,500 dilution of this antibody detected AXL in 30 µg of HepG2 cell lysate.
Purification Method:
Antigen Affinity purified
Presentation:
Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide and 50% glycerol.
Storage Conditions:
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
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UniProt Number:
P30530
Gene Symbol:
AXL
UFO
Alternate Names:
Tyrosine-protein kinase receptor UFO
AXL oncogene
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Product Name:
Anti-AXL Antibody
Concentration:
Please refer to the Certificate of Analysis for the lot-specific concentration.
Antibody Type:
Polyclonal Antibody
Qty/Pk:
150 µL
Format:
Affinity Purified
Host:
Rabbit
Applications:
Anti-AXL detects levels of AXL proteins & has been published & validated for use in WB.

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