Anti-AMPylated Tyrosine

货号： ABS184      产品名称： Anti-AMPylated Tyrosine   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-AMPylated Tyrosine
Species Reactivity Key Applications Host Format Antibody Type
H  WB Rabbit Serum Polyclonal Antibody
Description:
Anti-AMPylated Tyrosine Antibody
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Specificity:
This antibody recognizes AMPylated Tyrosines.
Molecular Weight:
~21 kDa observed. Molecular weights will vary based on the protein being AMPylated.
Isotype:
IgG
Background Information:
AMPylation is a reversible post-translational modification in which adenosine monophosphate (AMP) derived from ATP is added to threonine and tyrosine (and possibly serine) residues on target proteins. This modification is created by proteins containing Fic (filamentation induced by cyclic adenosine monophosphate) domains, which are present in both prokaryotic and eukaryotic cells. In mammals, the HYPE protein is the most widely known Fic-containing protein and the precise function of its AMPylated targets is not yet clear. However, bacterial cells possess numerous Fic-domain proteins that modify and disable protein targets in host cells, thereby suppressing signaling pathways and increasing the robustness of pathogenic infections. The Vibrio parahaemolyticus VopS protein, for instance, disrupts the function of Rho guanine triphosphatases, and eventually disrupts the actin cytoskeleton.
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Species Reactivity:
Human
Species Reactivity Note:
Demonstrated to react with Human. Broad species reactivity expected, as AMPylation is evolutionarily conserved.
Control:
Rac1, AMPylated in vitro
Quality Assurance:
Evaluated by Western Blot in Rac1, AMPylated in vitro.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected AMPylated Tyrosine on 10 ng of Rac1, AMPylated in vitro.
Purification Method:
Unpurified
Presentation:
Rabbit polyclonal serum containing 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Alternate Names:
AMPylated Tyrosine
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Product Name:
Anti-AMPylated Tyrosine
Antibody Type:
Polyclonal Antibody
Qty/Pk:
100 µL
Format:
Serum
Host:
Rabbit
Applications:
Anti-AMPylated Tyrosine Antibody detects level of AMPylated Tyrosine & has been published & validated for use in Western Blotting.

-20℃