Anti-phospho-mTOR (Thr2164)

货号： ABS88      产品名称： Anti-phospho-mTOR (Thr2164)   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-phospho-mTOR (Thr2164)
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REFERENCES
mTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression.
Ekim, Bilgen, et al. (2011) Mol. Cell. Biol., 31: 2787-801 (2011)
Species Reactivity Key Applications Host Format Antibody Type
H  DB, WB Rabbit Serum Polyclonal Antibody
Description:
Anti-phospho-mTOR (Thr2164) Antibody
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Specificity:
This antibody recognizes mTOR phosphorylated at Thr2164.
Molecular Weight:
289 kDa calculated
Epitope:
Phosphorylated Thr2164
Immunogen:
KLH-conjugated linear peptide corresponding to human mTOR phosphorylated at Thr2164.
Background Information:
The mammalian target of rapamycin (mTOR), also known as FRAP, RAFT, or RAPT, is a ubiquitously expressed serine/threonine kinase that belongs to the phosphoinositide 3-kinase–related kinase (PIKK) family. mTOR functions as a downstream effector in the PI3K pathway and is activated by the Akt kinase. mTOR responds to signals from growth factors and promotes protein synthesis underlying cell proliferation, by activation of the S6 kinase and inhibition of the 4E-BP protein involved in protein translation. Several studies have suggested that the proliferative functions of mTOR may contribute to the development of cancer.
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Species Reactivity:
Human
Species Reactivity Note:
Demonstrated to react with Human.
Application Notes:
Western Blot Analysis: A representative lot was used by an independent laboratory in HEK293 cell lysate. (Ekim, B., et al. (2011). MCB. [Epub ahead of print].)
Control:
Unmodified and phosphorylated mTOR peptides
Quality Assurance:
Dot Blot Specificity Analysis: Unmodified and phosphorylated mTOR peptides were probed with Anti-phospho-mTOR (Thr2164) (1:1,000 dilution).
Purification Method:
Unpurified
Presentation:
Rabbit polyclonal serum containing 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
UniProt Number:
P42345
Entrez Gene Number:
NP_004949
Gene Symbol:
MTOR
FRAP
FRAP1
FRAP2
RAFT1
RAPT1
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Alternate Names:
Serine/threonine-protein kinase mTOR
FK506-binding protein 12-rapamycin complex-associated protein 1
FKBP12-rapamycin complex-associated protein
Mammalian target of rapamycin
mTOR
Mechanistic target of rapamycin
Rapamycin and FKBP12 target 1
Rapamycin target protein 1
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Dot Blot
Western Blotting
Product Name:
Anti-phospho-mTOR (Thr2164)
Antibody Type:
Polyclonal Antibody
Qty/Pk:
100 µL
Format:
Serum
Host:
Rabbit
Applications:
Anti-phospho-mTOR (Thr2164) Antibody is an antibody against phospho-mTOR (Thr2164) for use in Dot Blot, W -20℃