Anti-T-cadherin (CDH13)
货号： ABT121 产品名称： Anti-T-cadherin (CDH13) 品牌： Millipore 规格： EA 三周到货 生化实验
Anti-T-cadherin (CDH13)
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Species Reactivity Key Applications Host Format Antibody Type
H, R, B, Eq, M WB, IH(P) Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-T-cadherin (CDH13) Antibody
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Specificity:
This antibody recognizes T-cadherin at the Cadherin 1 domain. This antibody detects the ~130 kDa pro-protein and the proteolytically cleaved ~105 kDa mature isoforms. (Denzel, M., et al. (2010). J Clin Invest.120(12):4342–4352.)
Molecular Weight:
~130 and ~105 kDa observed.
~130 kDa corresponds to the pro-protein and ~105 kDa corresponds to the proteolytically cleaved mature isoform. (Denzel, M., et al. (2010). J Clin Invest.120(12):4342–4352.)
Epitope:
Cadherin 1 domain
Immunogen:
KLH-conjugated linear peptide corresponding to human T-cadherin at the Cadherin 1 domain.
Background Information:
T-cadherin (CDH13), also known as Cadherin 13, is a member of the cadherin superfamily. This protein is unique from its other family members in that it lacks the cytoplasmic domains and is anchored to the cells membrane through the GPI anchor. T-cadherin is widely expressed in the cardiovascular system. Mutations in T-cadherin have been associated with many types of cancer.
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Species Reactivity:
Human
Rat
Bovine
Horse
Mouse
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Species Reactivity Note:
Demonstrated to react with Human and Rat. Predicted to react with Bovine, Equine, and Mouse based on 100% sequence homology.
Application Notes:
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected T-cadherin in human brain and human heart tissues.
Control:
Human heart tissue lysate
Quality Assurance:
Evaluated by Western Blot in human heart tissue lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected T-cadherin on 10 µg of human heart tissue lysate.
Purification Method:
Affinity purified
Presentation:
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
P55290
Entrez Gene Number:
NP_001248
Gene Symbol:
CDH13
CDHH
Alternate Names:
Cadherin-13
Heart cadherin
H-cadherin
P105
Truncated cadherin
T-cad
T-cadherin
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Immunohistochemistry (Paraffin)
Entrez Gene Summary:
This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. 2-8℃
