pUNO1-bTLR7

货号： puno1-btlr7      产品名称： pUNO1-bTLR7   品牌： Invivogen 规格： 1 disk 三周到货 生化试验

TLR7 Native Genes
Toll-Like Receptor 7 native genes in expression plasmid
Alias: CD287
TLR7 is abundantly expressed in lung, placenta, spleen and BPL [1].
TLR7 is phylogenetically close to TLR8 and TLR9 and has a higher molecular weight when compared with hTLR1-6, largely as a result of a longer ectodomain [2].
The natural ligand for TLR7 has not yet been identified. However, studies with TLR7-deficient mice have shown that TLR7 recognizes imidazoquinoline compounds, such as R848, a small synthetic antiviral molecule [3]. Imidazoquinoline signaling involves the MyD88-dependent signaling cascade and induces the production of IFN-α, TNF-α and IL-12.
This gene is available in pUNO1 expression plasmid selectable with Blasticidin or in pUNO3 expression plasmid selectable with Hygromycin or in pUNO1 expression plasmid selectable with Blasticidin.
Bovine TLR7 (pUNO1-bTLR07)
Genbank: NM_001033761.1
ORF Size: 3177 bp
Subclone: AgeI – NheI
Human TLR7 (pUNO1-hTLR07)
ORF Size: 3150 bp
Subclone: AgeI – NheI
Human TLR7 (pUNO3-hTLR07)
ORF Size: 3150 bp
Subclone: AgeI – NheI
Mouse TLR7 (pUNO1-mTLR07)
Genbank: NM_133211.3
ORF Size: 3153 bp
Subclone: AgeI – NheI
Pig TLR7 (pUNO1-pTLR07)
ORF Size: 3153 bp
Subclone: AgeI – NheI