pUNO1-bTLR9

货号： puno1-btlr9      产品名称： pUNO1-bTLR9   品牌： Invivogen 规格： 1 disk 三周到货 生化试验

TLR9 Native Genes
Toll-Like Receptor 9 native genes in expression plasmid
Alias: CD289
TLR9 is expressed in the endoplasmic reticulum of resting cells in contrast to most TLRs that are located on the plasma membrane [1].
TLR9 recognizes specific unmethylated CpG-ODN sequences, that distinguish bacterial DNA from mammalian DNA. TLR9 engages an intracellular signaling pathway that involves MyD88 leading to NF-κB translocation [2].
TLR9 recognizes different CpG motifs; the optimal sequences being GTCGTT and GACGTT for human TLR9 and murine TLR9 respectively [3]. TLR9 binds directly to CpG DNA and recognizes specifically CpG DNA that is unmethylated and single stranded [4].
This gene is available in pUNO1 expression plasmid selectable with Blasticidin or in pUNO3 expression plasmid selectable with Hygromycin or in pUNO1 expression plasmid selectable with Blasticidin.
Bovine TLR9 (pUNO1-bTLR09)
Genbank: EF076731
ORF Size: 3090 bp
Subclone: AgeI – NheI
Human TLR9 isoform 1 (pUNO1-hTLR09a)
ORF Size: 3099 bp
Subclone: MluI – NheI
Human TLR9 isoform 1 (pUNO3-hTLR09a)
ORF Size: 3099 bp
Mouse TLR9 (pUNO1-mTLR09)
ORF Size: 3099 bp
Subclone: AgeI – NheI
Pig TLR9 (pUNO1-pTLR09)
Genbank: AY859728.1
ORF Size: 3093 bp
Subclone: AgeI – NheI