pFUSE-mIgG2Ae1-Fc2

货号： pfc2-mg2ae1      产品名称： pFUSE-mIgG2Ae1-Fc2   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-mIgG2Ae1-Fc
pFUSE-mIgG2Ae1-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the murine IgG2 heavy chain mutated L235E + E318A/K320A/K322A and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-mIgG2Ae1-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype : IgG2a mouse
Mutations: L235E + E318A/K320A/K322A
Characteristics:
– Reduced binding to FcγRI and C1q
– Reduced ADCC and CDC
Both plasmids are selectable with Zeocin™.