A HU MARCKS 200UL

货号： 05-337      产品名称： A HU MARCKS 200UL   品牌： Millipore 规格： EA 3周到货 生化实验

Anti-MARCKS Antibody, clone 2F12
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REFERENCES
20-Hydroxyeicosatetraenoic acid-induced vasoconstriction and inhibition of potassium current in cerebral vascular smooth muscle is dependent on activation of protein kinase C
Lange, A., et al (1997) J Biol Chem, 272:27345-52 (1997)
Species Reactivity Key Applications Host Format Antibody Type
B, H  IP, WB Mouse Ascites Monoclonal Antibody
Description:
Anti-MARCKS Antibody, clone 2F12
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Trade Name:
Upstate (Millipore)
Specificity:
MARCKS
Molecular Weight:
none given
Immunogen:
Purified recombinant human MARCKS; Epitope mapped to the carboxyl-terminal.
Clone:
2F12
Isotype:
IgG1
Species Reactivity:
Bovine
Human
Quality Assurance:
routinely evaluated by immunoblot on bovine brain extract
Purification Method:
Ascites
Presentation:
mouse ascites containing 0.05% sodium azide
Storage Conditions:
6 months at -20°C
UniProt Number:
P29966
Entrez Gene Number:
NM_002356
Gene Symbol:
MARCKS
80K-L
MACS
PRKCSL
FLJ14368
phosphomyristin
MRACKS
PKCSL
FLJ90045
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunoprecipitation
Western Blotting
Entrez Gene Summary:
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.
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UniProt Summary:
FUNCTION: SwissProt: P29966 # MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.
SIZE: 332 amino acids; 31555 Da
PTM: Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.
SIMILARITY: SwissProt: P29966 ## Belongs to the MARCKS family.
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Brand Family:
Upstate
Product Name:
Anti-MARCKS Antibody, clone 2F12
Antibody Type:
Monoclonal Antibody
Qty/Pk:
200 µL
Target / Localization:
Soma
Format:
Ascites
Host:
Mouse
Applications:
Anti-MARCKS Antibody, clone 2F12 detects level of MARCKS & has been published & validated for use in IP & WB.

-20°C