a-NR2B, clone BWJHL 100ug

货号： 05-920      产品名称： a-NR2B, clone BWJHL 100ug   品牌： Millipore 规格： EA 3周到货 生化实验

Anti-NR2B Antibody, clone BWJHL
Close
REFERENCES
Brain-derived neurotrophic factor-tyrosine kinase B pathway mediates NMDA receptor NR2B subunit phosphorylation in the supraoptic nuclei following progressive dehydration.
F R Carreño,J D Walch,M Dutta,T P Nedungadi,J T Cunningham,F R Carreño (2011) Journal of neuroendocrinology.23
Amino terminal domain regulation of NMDA receptor function.
Herin, Greta Ann and Aizenman, Elias (2004) Eur. J. Pharmacol., 500: 101-11 (2004)
Roles of diverse glutamate receptors in brain functions elucidated by subunit-specific and region-specific gene targeting.
Mori, Hisashi and Mishina, Masayoshi (2003) Life Sci., 74: 329-36 (2003)
Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease.
Li, Lijun, et al. (2003) Neurobiol. Aging, 24: 1113-21 (2003)
View All
Species Reactivity Key Applications Host Format Antibody Type
H, R  WB Mouse Purified Monoclonal Antibody
Description:
Anti-NR2B Antibody, clone BWJHL
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Specificity:
NR2B
Molecular Weight:
Mr 180kDa
Immunogen:
GST fusion protein corresponding to residues 934-1457 of rat NR2B. Clone BWJHL.
Isotype:
IgG
Species Reactivity:
Human
Rat
Quality Assurance:
routinely evaluated by immunoblot on rat brain microsomal preparations (Catalog#12-144)
Purification Method:
Protein G purfied
Storage Conditions:
stable 2 years at -20°C from date of shipment
UniProt Number:
Q13224
Entrez Gene Number:
NM_012574
Gene Symbol:
GRIN2B
Glutamate
MGC142178
MGC142180
NR2B
NMDAR2B
NR3
hNR3
View All »
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Western Blotting
Entrez Gene Summary:
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.
View All »
UniProt Summary:
FUNCTION: SwissProt: Q13224 # NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.
SIZE: 1484 amino acids; 166367 Da
SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4 (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal -20°C