ANTI-EMT/ITK/TSK PC 12-303
货号： 06-546 产品名称： ANTI-EMT/ITK/TSK PC 12-303 品牌： Millipore 规格： EA 3周到货 生化实验
Anti-Itk/Emt/Tsk Antibody
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REFERENCES
In Vivo Consequences of Disrupting SH3-Mediated Interactions of the Inducible T-Cell Kinase.
Roman M Levytskyy,Nupura Hirve,David M Guimond,Lie Min,Amy H Andreotti,Constantine D Tsoukas (2012) Journal of signal transduction.2012
The EMT/ITK/TSK (EMT) tyrosine kinase is activated during TCR signaling: LCK is required for optimal activation of EMT.
Gibson, S, et al. (1996) J. Immunol., 156: 2716-22 (1996)
Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells.
Yamada, N, et al. (1993) Biochem. Biophys. Res. Commun., 192: 231-40 (1993)
Species Reactivity Key Applications Host Format Antibody Type
H, M IP, WB Rabbit Purified Polyclonal Antibody
Description:
Anti-Itk/Emt/Tsk Antibody
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Trade Name:
Upstate (Millipore)
Specificity:
Itk/Emt/Tsk
Molecular Weight:
72 kDa
Immunogen:
Itk/Emt/Tsk-GST fusion protein (Itk/Emt/Tsk amino acid residues 1-270) spanning the PH, SH3 domains and a small portion of the SH2 domain
Isotype:
IgG
Species Reactivity:
Human
Mouse
Quality Assurance:
routinely evaluated by immunoblot on Jurkat cell RIPA lysate
Purification Method:
Protein A chromatography
Presentation:
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Storage Conditions:
2 years at -20°C
UniProt Number:
Q08881
Entrez Gene Number:
NM_005546
Gene Symbol:
ITK
LYK
PSCTK2
EMT
MGC126258
MGC126257
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunoprecipitation
Western Blotting
Entrez Gene Summary:
This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation.
UniProt Summary:
FUNCTION: SwissProt: Q08881 # Plays a role in T-cell proliferation and differentiation.
COFACTOR: Binds 1 zinc ion per subunit (By similarity).
SIZE: 620 amino acids; 71831 Da
SUBCELLULAR LOCATION: Cell membrane (By similarity). Note=Localizes to cell surface receptors in the plasma membrane after stimulation with respective receptors (TCR, CD28, CD2) in T- cells (By similarity).
TISSUE SPECIFICITY: T-cell lines and natural killer cell lines.
SIMILARITY: SwissProt: Q08881 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. & Contains 1 Btk-type zinc finger. & Contains 1 PH domain. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
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Brand Family:
Upstate
Product Name:
Anti-Itk/Emt/Tsk Antibody
Antibody Type:
Polyclonal Antibody
Qty/Pk:
250 µg
Format:
Purified
Host:
Rabbit
Applications:
This Anti-Itk/Emt/Tsk Antibody is validated for use in IP, WB for the detection of Itk/Emt/Tsk.
-20°C
