ANTI-MOESIN PC 12-305

货号： 07-121      产品名称： ANTI-MOESIN PC 12-305   品牌： Millipore 规格： EA 3周到货 生化实验

Anti-Moesin Antibody
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REFERENCES
Expression level, subcellular distribution and rho-GDI binding affinity of merlin in comparison with Ezrin/Radixin/Moesin proteins.
Maeda, M, et al. (1999) Oncogene, 18: 4788-97 (1999)
Moesin, like ezrin, colocalizes with actin in the cortical cytoskeleton in cultured cells, but its expression is more variable.
Franck, Z, et al. (1993) J. Cell. Sci., 105 ( Pt 1): 219-31 (1993)
Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype
Yang, H. S. and Hinds, P. W. (2003) Mol Cell, 11:1163-76 (2003)
Species Reactivity Key Applications Host Format Antibody Type
H, M, R  WB Rabbit Purified Polyclonal Antibody
Description:
Anti-Moesin Antibody
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Trade Name:
Upstate (Millipore)
Specificity:
Moesin
Molecular Weight:
78kDa
Immunogen:
peptide corresponding to amino acids 401-413 of human Moesin (C-EALLQASRDQKKT)
Isotype:
IgG
Species Reactivity:
Human
Mouse
Rat
Quality Assurance:
routinely evaluated by immunoblot on HeLa, A431, Jurkat, HFF, Raji, 3T3, CTLL, L6 or PC-12 cell lysates
Purification Method:
Protein A chromatography
Presentation:
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, and 0.05% sodium azide.
Storage Conditions:
2 years at -20°C
UniProt Number:
P26038
Entrez Gene Number:
NM_002444
Gene Symbol:
MSN
Moesin
moesin
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement.
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UniProt Summary:
FUNCTION: SwissProt: P26038 # Probably involved in connections of major cytoskeletal structures to the plasma membrane.
SIZE: 577 amino acids; 67820 Da
SUBUNIT: In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation (By similarity). Binds SLC9A3R1.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Note=Phosphorylated form is enriched in microvilli-like structures at apical membrane (By similarity).
TISSUE SPECIFICITY: In all tissues and cultured cells studied.
PTM: Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures (By similarity).
SIMILARITY: SwissProt: P26038 ## Contains 1 FERM domain.
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Brand Family:
Upstate
Product Name:
Anti-Moesin Antibody
Antibody Type:
Polyclonal Antibody
Qty/Pk:
200 µg
Format:
Purified
Host:
Rabbit
Applications:
This Anti-Moesin Antibody is validated for use in WB for the detection of Moesin.

-20°C