sFRP-4, RBX-100UL
货号： 09-129 产品名称： sFRP-4, RBX-100UL 品牌： Millipore 规格： EA 三周到货 生化实验
Anti-SFRP4 Antibody
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REFERENCES
A system-wide investigation of the dynamics of Wnt signaling reveals novel phases of transcriptional regulation.
Taranjit S Gujral,Gavin MacBeath (2010) PloS one.5
Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells
He, Biao, et al (2005) Cancer Res, 65:743-8 (2005)
Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells
Roth, W, et al (2000) Oncogene, 19:4210-20 (2000)
Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro
Horvath, Lisa G, et al (2004) Clin Cancer Res, 10:615-25 (2004)
Species Reactivity Key Applications Host Format Antibody Type
H WB Rabbit Serum Polyclonal Antibody
Description:
Anti-SFRP4 Antibody
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes SFRP4
Molecular Weight:
55 kDa
Immunogen:
Recombinant full length human GST-tagged SFRP4 protein.
Isotype:
IgG
Species Reactivity:
Human
Application Notes:
Immunoblot: 1:500-1:5000 dilution is recommended depending on cell type and method of stimulation.
Optimal working dilutions must be determined by end user.
Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Serum
UniProt Number:
Q6FHJ7
Entrez Gene Number:
NM_003014.2
Gene Symbol:
SFRP4
sFRP-4
FRPHE
frpHE
MGC26498
FRP-4
FrpHE
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Alternate Names:
secreted frizzled-related protein 4, FRP-4, sFRP-4, FRPHE
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression.
UniProt Summary:
FUNCTION: SwissProt: Q6FHJ7 # Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.
SIZE: 346 amino acids; 39827 Da
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes.
DOMAIN:SwissProt: Q6FHJ7 The FZ domain is involved in binding with Wnt ligands (By similarity).
DISEASE:SwissProt: Q6FHJ7 # Associated with tumor-induced osteomalacia, a disorder in which there is an increase in renal phosphate excretion and a reduction in serum phosphate levels leading to hyperphosphaturia, hypophos -20℃
