BRK, RBX, -MG

货号： 09-143-K      产品名称： BRK, RBX, -MG   品牌： Millipore 规格： MG 三周到货 生化实验

Anti-Brk Antibody
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REFERENCES
Growth response of Escherichia coli ATCC 35218 adapted to several concentrations of sodium benzoate and potassium sorbate.
Santiesteban-López NA, Rosales M, Palou E, López-Malo A (2009) J Food Prot.72:2301-7.
The intracellular tyrosine kinase Brk sensitizes non-transformed cells to inducers of apoptosis
Haegebarth, Andrea, et al (2005) Cell Cycle, 4:1239-46 (2005)
Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition
Qiu, Haoqun and Miller, W Todd (2002) J Biol Chem, 277:34634-41 (2002)
Interaction between Brk kinase and insulin receptor substrate-4
Qiu, Haoqun, et al (2005) Oncogene, 24:5656-64 (2005)
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Species Reactivity Key Applications Host Format Antibody Type
H  WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-Brk Antibody
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes Brk (breast tumor kinase, PTK6) at approximately 52 kDa. It can also recognize the 73 kDa ELF-related protein that shares 70% homology with the immunizing peptide.
Molecular Weight:
52 kDa
Immunogen:
KLH conjugated synthetic peptide corresponding to the N-terminal region of human Brk.
Isotype:
IgG
Species Reactivity:
Human
Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Immunoaffinity purified
Presentation:
50 µg of affinity purified rabbit polyclonal IgG in 0.02 M PBS, 250 mM sodium chloride containing 0.1% sodium azide.
Storage Conditions:
Store for 1 year at 2-8°C from date of shipment.
UniProt Number:
Q13882
Entrez Gene Number:
NM_005975.2
Gene Symbol:
PTK6
BRK
FLJ42088
Alternate Names:
PTK6, protein tyrosine kinase 6, breast tumor kinase, protein-tyrosine kinase BRK,
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation.
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UniProt Summary:
FUNCTION: SwissProt: Q13882 # Phosphorylates KHDRBS1, KHDRBS2, KHDRBS3 and STAP2/BKS. May function as an intracellular signal transducer in epithelial tissues. Overexpression in mammary cells leads to mitogenically sensitization to EGF, and results in a partially transformed phenotype. Its presence in the nucleus appears to be linked to suppression of tumor progression.
SIZE: 451 amino acids; 51834 Da
SUBUNIT: Interacts with GAP-A.p65 (By similarity). Interacts with KHDRBS1.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Colocalizes with KHDRBS1, KHDRBS2 or KHDRBS3, within the nucleus. In secretory epithelial cells from prostate adenocarcinoma, nuclear localization is higher in low-grade and l 2-8℃