(S)-(+)-Camptothecin

货号： ALX-350-015-M050      产品名称： (S)-(+)-Camptothecin   品牌： Alexis 规格： 50 mg 3周到货 生化实验

(S)-(+)-Camptothecin
Potent antitumor agent
Potent antitumor agent. Inhibitor of DNA-topoisomerase I. Activates p53 resulting in upregulated expression of TRAIL-R2 (DR5) and Bak to overcome TRAIL resistance in Bax-deficient human colon carcinoma cells. Inhinbits Tat-mediated transactivation of HIV-1. Induces apoptosis in osteosarcoma and hepatoma cells. Suppresses nitric oxide (NO) biosynthesis.
Product Specification
Formula: C20H16N2O4
MW: 348.4
Source: Isolated from Mappia foetida Miers (Nothapodytes foetida (Wt.) Sleumer).
CAS: 7689-03-4
MI: 14: 1735
RTECS: UQ0492000
Purity: ≥98% (HPLC)
Appearance: Pale yellow powder.
Hazard: TOXIC.
Solubility: Soluble in DMSO (10mg/ml), methanol (40mg/ml), 0.1N sodium hydroxide (50mg/ml) or acetic acid; insoluble in water.
Long Term Storage: +4°C
Handling: Protect from light and moisture. After reconstitution, prepare aliquots and store at -20°C.

+4°C