标签： vwf

190319005   CAPTURESELECT VWF AFF MTR   品牌 Invitrogen

CAPTURESELECT VWF AFF MTR

货号： 190319005      产品名称： CAPTURESELECT VWF AFF MTR   品牌： Invitrogen 规格： *** 三周到货 生化试验

CaptureSelect™ von Willebrand Factor Affinity Matrix
This is one of a group of CaptureSelect™ protein purification affinity resins developed for the simple, single-step purification of a variety human plasma and serum proteins. This unique selection of affinity purification resins can purify proteins or other non-antibody biomolecules from either recombinant or native sources with a high degree of affinity and specificity, and are immobilized on a high capacity agarose support.
Format: Bulk Media 
Product Size: 5 mL 
Immobilized Phase: Anti Von Willebrand 
Column or Resin Type: Bulk Resins
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Store at 2–8°C.

190319010   CAPTURESELECT VWF AFF MTR   品牌 Invitrogen

CAPTURESELECT VWF AFF MTR

货号： 190319010      产品名称： CAPTURESELECT VWF AFF MTR   品牌： Invitrogen 规格： *** 三周到货 生化试验

CaptureSelect™ von Willebrand Factor Affinity Matrix
This is one of a group of CaptureSelect™ protein purification affinity resins developed for the simple, single-step purification of a variety human plasma and serum proteins. This unique selection of affinity purification resins can purify proteins or other non-antibody biomolecules from either recombinant or native sources with a high degree of affinity and specificity, and are immobilized on a high capacity agarose support.
Format: Bulk Media 
Product Size: 10 mL 
Immobilized Phase: Anti Von Willebrand 
Column or Resin Type: Bulk Resins
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Store at 2–8°C.

190319050   CAPTURESELECT VWF AFF MTR   品牌 Invitrogen

CAPTURESELECT VWF AFF MTR

货号： 190319050      产品名称： CAPTURESELECT VWF AFF MTR   品牌： Invitrogen 规格： *** 三周到货 生化试验

CaptureSelect™ von Willebrand Factor Affinity Matrix
This is one of a group of CaptureSelect™ protein purification affinity resins developed for the simple, single-step purification of a variety human plasma and serum proteins. This unique selection of affinity purification resins can purify proteins or other non-antibody biomolecules from either recombinant or native sources with a high degree of affinity and specificity, and are immobilized on a high capacity agarose support.
Format: Bulk Media 
Product Size: 50 mL 
Immobilized Phase: Anti Von Willebrand 
Column or Resin Type: Bulk Resins
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Store at 2–8°C.

05-861   Anti-vWF(von Willebrand Factor), clone G   品牌 Millipore

Anti-vWF(von Willebrand Factor), clone G

货号： 05-861      产品名称： Anti-vWF(von Willebrand Factor), clone G   品牌： Millipore 规格： EA 3周到货 生化实验

Anti-vWF (von Willebrand Factor) Antibody, clone GMA-022
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REFERENCES
Shear stress and von Willebrand factor in health and disease.
Tsai, Han-Mou (2003) Semin. Thromb. Hemost., 29: 479-88 (2003)
Von Willebrand factor.
Ruggeri, Zaverio M (2003) Curr. Opin. Hematol., 10: 142-9 (2003)
Species Reactivity Key Applications Host Format Antibody Type
H  WB Mouse Purified Monoclonal Antibody
Description:
Anti-vWF (von Willebrand Factor) Antibody, clone GMA-022
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Specificity:
von Willebrand Factor
Molecular Weight:
260kDa
Immunogen:
Purified human von Willebrand Factor
Clone:
GMA-022
Isotype:
IgG1
Species Reactivity:
Human
Quality Assurance:
Routinely evaluated by immunoblot
Purification Method:
DEAE purified
Storage Conditions:
2 years at -20°C from date of shipment
UniProt Number:
P04275
Entrez Gene Number:
NM_000552
Gene Symbol:
VWF
F8
vWF
VWD
F8VWF
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand’s disease. An unprocessed pseudogene has been found on chromosome 22.
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UniProt Summary:
FUNCTION: SwissProt: P04275 # Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
SIZE: 2813 amino acids; 309299 Da
SUBUNIT: Multimeric. Interacts with F8.
SUBCELLULAR LOCATION: Secreted. Note=Localized to storage granules.
TISSUE SPECIFICITY: Plasma.
DOMAIN: SwissProt: P04275 The von Willebrand antigen 2 is required for multimerization of VWF and for its targeting to storage granules.
PTM: All cysteine residues are involved in intrachain or interchain disulfide bonds.
DISEASE: SwissProt: P04275 # Defects in VWF are associated with various forms of von Willebrand disease (VWD) [MIM:193400, 277480]. VWD is characterized by frequent bleeding (gingival, minor skin quantitative lacerations, menorrhagia, etc.). Type I VWD is associated with a deficiency of VWF; type II by normal to decreased plasma level of VWF; type III by a virtual absence of VWF. There are subtypes (A to H) of type II VWD; for example: type IIA is characterized by the absence of VWF high molecular weight multimers in plasma.
SIMILARITY: Contains 1 CTCK (C-terminal cystine knot-like) domain. & Contains 4 TIL (trypsin inhibitory-like) domains. & Contains 3 VWFA domains. & Contains 3 VWFC domains. & Contains 4 VWFD domains.
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Brand Family:
Upstate
Product Name:

AB7356   VWF RBX-100UG   品牌 Millipore

VWF RBX-100UG

货号： AB7356      产品名称： VWF RBX-100UG   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-von Willibrand Factor Antibody
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REFERENCES
Reversal of endothelial progenitor cell dysfunction in patients with type 2 diabetes using a conditioned medium of human embryonic stem cell-derived endothelial cells.
Jenny C Y Ho,Wing-Hon Lai,Ming-Fang Li,Ka-Wing Au,Mei-Chu Yip,Navy L Y Wong,Ethel S K Ng,Francis F Y Lam,Chung-Wah Siu,Hung-Fat Tse (2012) Diabetes/metabolism research and reviews.28
Characterization of clonal vascular smooth muscle cell lines derived from young and old Fischer 344 rats.
William E Schutzer,Douglas R Beard,John F Reed,Scott L Mader (2011) In vitro cellular & developmental biology. Animal.47
Decellularization reduces immunogenicity of sheep pulmonary artery vascular patches.
Eric J Lehr,Gina R Rayat,Brian Chiu,Thomas Churchill,Locksley E McGann,James Y Coe,David B Ross (2011) The Journal of thoracic and cardiovascular surgery.141
Endothelial progenitor cells induce a phenotype shift in differentiated endothelial cells towards PDGF/PDGFR axis-mediated angiogenesis.
Moritz Wyler von Ballmoos,Zijiang Yang,Jan Völzmann,Iris Baumgartner,Christoph Kalka,Stefano Di Santo (2010) PloS one.5
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Species Reactivity Key Applications Host Format Antibody Type
H, M, R  ELISA, IH(P) Rabbit Purified Polyclonal Antibody
Description:
Anti-von Willibrand Factor Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Chemicon (Millipore)
Specificity:
AB7356 is specific for vWF by ELISA against the human protein and by immunohistochemistry. The antibody is reactive in paraffin embedded tissues on human, rat, and mouse. Other species not tested. Antibody has not been evaluated by western blot analysis for reactivity to vWF.
Molecular Weight:
250 kDa
Immunogen:
Human von Willebrand Factor purified from plasma.
Background Information:
von Willebrand Factor (vWF) is synthesized by endothelial cells, causing adhesion of platelets to injured vessel walls and functions as a carrier and stabilizer for coagulation of Factor VIII. It is one of the most widely used endothelial cell markers for studying angiogenesis / neovascularization.
Millipore’s von Willebrand Factor antibody reacts specifically with the endothelial cells of blood vessels and is a useful marker for the identification of endothelial lineage in tumors.
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Species Reactivity:
Human
Mouse
Rat
Species Reactivity Note:
Human, Mouse and Rat
Application Notes:
ELISA:
A 1:1000-1:5000 dilution of a previous lot was used in direct ELISA.
Optimal working dilutions must be determined by the end user.
Control:
POSITIVE CONTROL: Human tonsils, Mouse and rat brain.
Quality Assurance:
Immunohistochemistry(paraffin):
Representative images from a previous lot.
Rabbit anti-vWF (AB7356) staining of Human Cerebral Cortex. Tissue pretreated with Citrate Buffer, ph 6.0, anti-vWF at 20 μg/mL, IHC-Select Detection with HRP-DAB.
Purification Method:
Protein A purfied
Presentation:
Purified rabbit immunoglobulin in buffer containing 0.02 M PBS pH 7.6, 0.25 M NaCl with 0.1% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8ºC from date of receipt.
UniProt Number:
P04275
Entrez Gene Number:
NM_000552.3
Gene Symbol:
VWF
F8VWF
F8
vWF
VWD
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Alternate Names:
Factor VIII Related Antigen
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any oth 2-8℃