标签： estradiol

E2257   现货|17β-Estradiol|β-雌二醇|β-Estradiol|Dihydrofolliculin|17β-diol   品牌 Sigma

现货|17β-Estradiol|β-雌二醇|β-Estradiol|Dihydrofolliculin|17β-diol

货号： E2257      产品名称： 现货|17β-Estradiol|β-雌二醇|β-Estradiol|Dihydrofolliculin|17β-diol   品牌： Sigma 规格： 1MG原装 大量现货 细胞培养

E2257   现货|17β-Estradiol|β-雌二醇|β-Estradiol|Dihydrofolliculin|17β-diol   品牌 Sigma

 

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Sigma  E2257  β-Estradiol
powder, BioXtra, γ-irradiated,适用于细胞培养!
Synonym: 1,3,5-Estratriene-3,17β-diol, 17β-Estradiol, 3,17β-Dihydroxy-1,3,5(10)-estratriene, Dihydrofolliculin
CAS Number: 50-28-2
Empirical Formula (Hill Notation): C18H24O2
Molecular Weight: 272.38
Beilstein Registry Number: 1914275
Application
β-雌二醇可用于研究细胞分化和转化（肿瘤发生）。
Reconstitution
要制备 20μg/mL 的储存液，可加入 1mL 无水乙醇，温和搅拌使之溶解，在搅拌下加入 49mL 无菌培养基。
Physical form
室温下为粉末状；分成小份冻存，以避免使用时反复冷冻/解冻
Biochem/physiol Actions
由绝经前卵巢分泌的主要雌激素。雌激素在胚胎形成中以及在青春期，通过调控基因转录，并因此调控蛋白合成，从而指导女性表型的发展。它还可诱导促性腺激素的生成，继而诱导排卵。暴露于雌二醇将增加乳腺癌的发病率以及增加增生。
sterility :γ-irradiated
product line :BioXtra
form:powder
potency    0.2-10 ng/mL
mp    176-180 °C(lit.)
suitability    suitable for cell culture
Solubility (Color)             Colorless to Faint Yellow
Solubility (Turbidity)  Clear1 mg/mL, EtOH
Purity (HPLC) :> 98 %

RT

E7376-1 g   Estradiol   品牌 LKT

Estradiol

货号： E7376-1 g      产品名称： Estradiol   品牌： LKT 规格： 1 g 三周到货 生化试验

Estradiol      
Description
Potent mammalian estrogenic hormone, useful in the prevention of neuro degenerative diseases, such as Alzheimer’s and Parkinson disease, in both men and women. Found to be major steroid mitogen in premenopausal women.
Find out more information about other compounds related to Parkinson’s Disease 
See other Alzheimer’s Disease related products
Specifications 
Cas No. 50-28-2
Product ID  E7376
Product Name  Estradiol
Chemical Name  (17β)-Estra-1,3,5(10)-triene-3,17-diol
Synonym Dimenformon; Estrace; Estraderm; Evorel; Macrodiol; Menorest; Profoliol B; Systen; Vagifem; Zumenon
Formula Wt. 272.38
Melting Point 173
Purity ≥97% 
Solubility Soluble in alcohol, acetone, dioxane, and other organic solvent. Insoluble in water.
Store Temp Ambient
References Bhavnani BR.J Steroid Biochem Mol Biol. 85:473-82(2003). 
 

室温

E7376-25 g   Estradiol   品牌 LKT

Estradiol

货号： E7376-25 g      产品名称： Estradiol   品牌： LKT 规格： 25 g 三周到货 生化试验

Estradiol      
Description
Potent mammalian estrogenic hormone, useful in the prevention of neuro degenerative diseases, such as Alzheimer’s and Parkinson disease, in both men and women. Found to be major steroid mitogen in premenopausal women.
Find out more information about other compounds related to Parkinson’s Disease 
See other Alzheimer’s Disease related products 
Specifications 
Cas No. 50-28-2
Product ID  E7376
Product Name  Estradiol
Chemical Name  (17β)-Estra-1,3,5(10)-triene-3,17-diol
Synonym Dimenformon; Estrace; Estraderm; Evorel; Macrodiol; Menorest; Profoliol B; Systen; Vagifem; Zumenon
Formula Wt. 272.38
Melting Point 173
Purity ≥97% 
Solubility Soluble in alcohol, acetone, dioxane, and other organic solvent. Insoluble in water.
Store Temp Ambient
References Bhavnani BR.J Steroid Biochem Mol Biol. 85:473-82(2003). 
 

室温

E7376-5 g   Estradiol   品牌 LKT

Estradiol

货号： E7376-5 g      产品名称： Estradiol   品牌： LKT 规格： 5 g 三周到货 生化试验

Estradiol      
Description
Potent mammalian estrogenic hormone, useful in the prevention of neuro degenerative diseases, such as Alzheimer’s and Parkinson disease, in both men and women. Found to be major steroid mitogen in premenopausal women.
Find out more information about other compounds related to Parkinson’s Disease 
See other Alzheimer’s Disease related products
Specifications 
Cas No. 50-28-2
Product ID  E7376
Product Name  Estradiol
Chemical Name  (17β)-Estra-1,3,5(10)-triene-3,17-diol
Synonym Dimenformon; Estrace; Estraderm; Evorel; Macrodiol; Menorest; Profoliol B; Systen; Vagifem; Zumenon
Formula Wt. 272.38
Melting Point 173
Purity ≥97% 
Solubility Soluble in alcohol, acetone, dioxane, and other organic solvent. Insoluble in water.
Store Temp Ambient
References Bhavnani BR.J Steroid Biochem Mol Biol. 85:473-82(2003). 
 

室温

H9816-1 mg   2-Hydroxy Estradiol   品牌 LKT

2-Hydroxy Estradiol

货号： H9816-1 mg      产品名称： 2-Hydroxy Estradiol   品牌： LKT 规格： 1 mg 三周到货 生化试验

2-Hydroxy Estradiol
Description
2-hydroxy Estradiol (2-HE2) is a cytochrome P450 metabolite of estradiol with low affinity for estrogen receptors. 2-HE is rapidly metabolized by catechol-O-methyltransferase (COMT) to form 2-methoxy estradiol (2-ME2) with a half-life of approximately ten minutes in rat. 2-ME2 has achieved considerable attention as an anti-cancer agent acting as an angiogenesis inhibitor via the HIF-1a pathway. Due to the rapid metabolism of 2-HE2, the effects attributed to 2-HE2, may actually be those of 2-ME2.
Specifications 
Product ID  H9816
Product Name  2-Hydroxy Estradiol
References Becker, C.M., Rohwer, N., Funakoshi, T., et al. 2-methoxyestradiol inhibits hypoxia-inducible factor-1a and suppressess growth of lesions in a mouse model of endometriosis. Am J Pathol 172(2) 534-544 (2008). Mooberry, S.L. Mechanism of action of 2-methoxyestradiol: New developments. Drug Resist Updat 6 355-361 (2003). Mooberry, S.L. New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent. Curr Opin Oncol 15 425-430 (2003). Zacharia, L.C., Piché, C.A., Fielding, R.M., et al. 2-hydroxyestradiol is a prodrug of 2-methoxyestradiol. J Pharmacol Exp Ther 309(3) 1093-1097 (2004).
 

H9816-10 mg   2-Hydroxy Estradiol   品牌 LKT

2-Hydroxy Estradiol

货号： H9816-10 mg      产品名称： 2-Hydroxy Estradiol   品牌： LKT 规格： 10 mg 三周到货 生化试验

2-Hydroxy Estradiol
Description
2-hydroxy Estradiol (2-HE2) is a cytochrome P450 metabolite of estradiol with low affinity for estrogen receptors. 2-HE is rapidly metabolized by catechol-O-methyltransferase (COMT) to form 2-methoxy estradiol (2-ME2) with a half-life of approximately ten minutes in rat. 2-ME2 has achieved considerable attention as an anti-cancer agent acting as an angiogenesis inhibitor via the HIF-1a pathway. Due to the rapid metabolism of 2-HE2, the effects attributed to 2-HE2, may actually be those of 2-ME2.
Specifications 
Product ID  H9816
Product Name  2-Hydroxy Estradiol
References Becker, C.M., Rohwer, N., Funakoshi, T., et al. 2-methoxyestradiol inhibits hypoxia-inducible factor-1a and suppressess growth of lesions in a mouse model of endometriosis. Am J Pathol 172(2) 534-544 (2008). Mooberry, S.L. Mechanism of action of 2-methoxyestradiol: New developments. Drug Resist Updat 6 355-361 (2003). Mooberry, S.L. New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent. Curr Opin Oncol 15 425-430 (2003). Zacharia, L.C., Piché, C.A., Fielding, R.M., et al. 2-hydroxyestradiol is a prodrug of 2-methoxyestradiol. J Pharmacol Exp Ther 309(3) 1093-1097 (2004).