BD-1, human recombinant

货号： 4506-20      产品名称： BD-1, human recombinant   品牌： Biovision 规格： 20 μg 3周到货 生化实验

BD-1, human recombinant
An antimicrobial peptide
Product Overview
Alternate Names / Synonyms: BD-1, BD1, BD 1
Gene Symbol: DEFB1
Accession #: P60022
Gene ID: 1672
Source: E. coli
Appearance: Lyophilized protein
Physical Form Description: Lyophilized from a concentrated (1 mg/ml) solution containing 20 mM PBS pH-7.4 and 130 mM sodium chloride
Molecular Weight: 5.0 kDa
Purity by SDS-PAGE: ≥98%
Purity by HPLC: N/A
Endotoxin Level: <0.1 ng/μg
Biological Activity: Determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 0.1-1 µg/ml.
Reconstitution Instructions: Reconstitute in dH₂O to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
Storage Temp.: -20°C
Shipping: Gel pack
Background Information: The Defensin family are highly similar in their protein sequence and are microbicidal & cytotoxic peptides made by neutrophils. β Defensin-1 (BD-1) is an antimicrobial peptide having the resistance of epithelial surfaces to microbial colonization. BD-1 has close proximity to Defensin α-1 and has been implicated in the pathogenesis of cystic fibrosis. Skin of patients having atopic dermatitis patients and mycosis fungoides (non-lesional and lesional) show lower human BD-1 mRNA expression and higher human BD-2 and human BD-3 mRNA expression. β Defensin is highly expressed by epithelial cells. BD-1 may play a role in the pathogenesis of severe sepsis. Variation in human BD-1 contributes to asthma diagnosis, with apparent gender-specific effects. Human BD-3 is a dimer, while Human BD-1 and Human BD-2 are monomeric. Recombinant human β Defensin-1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 47 amino acids and having a molecular mass of 5 kDa.
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans.

-20°C