BCMA, human recombinant

货号： 4521-20      产品名称： BCMA, human recombinant   品牌： Biovision 规格： 20 μg 3周到货 生化实验

BCMA (TNFRSF17), Human recombinant
A member of the TNF receptor superfamily
Product Overview
Alternate Names / Synonyms:
Gene Symbol: TNR17
Accession #: Q02223
Gene ID: 608
Source: E. coli
Appearance: Lyophilized protein
Physical Form Description: Lyophilized from a solution containing 20 mM PBS, pH-7.4, and 130 mM NaCl.
Molecular Weight: 5.3 kDa
Purity by SDS-PAGE: ≥98%
Purity by HPLC: N/A
Endotoxin Level: <0.1 ng/μg
Biological Activity: N/A
Reconstitution Instructions: It is recommended to reconstitute the lyophilized BCMA in sterile dH₂O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Storage Temp.: -20°C
Shipping: Gel pack
Background Information: BCMA, also named TNFRSF17, is a receptor for tnfsf13b/blys/baff and tnfsf13/april. TNFRSF17 promotes b-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 activates nf-κ-b and jnk. TNFRSF17 is a member of the TNF-receptor superfamily. TNFRSF17 is expressed in mature B lymphocytes, and is invloved in B cell development and autoimmune response. TNFRSF17 specifically binds to the tumor TNFSF13B/TALL-1/BAFF, which causes NF-κB and MAPK8/JNK activation. TNFRSF17 binds to a variety of TRAF family members, and therefore transduces signals for cell survival and proliferation. TNFRSF17 is a type III membrane protein having 1 extraCellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs. TNFRSF17 appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells. Recombinant human TNFRSF17 produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 50 amino acids and having a molecular mass of 5.3 kDa.
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans.

-20°C