BD-4, human recombinant

货号： 4525-20      产品名称： BD-4, human recombinant   品牌： Biovision 规格： 20 μg 3周到货 生化实验

BD-4, human recombinant
An antimicrobial peptide
Product Overview
Alternate Name/Synonyms: human BD-4, h-BD-4, rh-BD-4, recombinant human BD-4, recombinant BD-4, BD, BD4, BD-4, BD 4
Gene Symbol: DEFB4
Accession #: Q8WTQ1
Gene ID: 140596
Source: E. coli
Appearance: Lyophilized protein
Physical Form Description: Sterile filtered and lyophilized from 20 mM PBS, pH 7.4 and 130 mM NaCl
Molecular Weight: ~6.0 kDa
Purity by SDS-PAGE: ≥98%
Purity by HPLC: ≥98%
Endotoxin Level: N/A
Biological Activity: Determined by its ability to chemoattract human monocytes using a concentration range of 0.1-50 ng/ml
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile dd water to a concentration ≥ 100 µg/ml. This solution can then be diluted into other aqueous buffers and stored at 4 °C for 2-7 days and at -20 °C for future use
Storage Temp.: -20°C
Shipping: Gel Pack
Background Information: Defensins are cationic peptides with a large spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The Alpha defensins are differentiated from the Beta-defensins by the pairing of their 3 disulfide bonds. Four human Beta-defensins have been identified to date; BD-1, BD-2, BD-3 and BD-4. Beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. Beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence (for BD-1 a propeptide region). Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Beta Defensin-4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 50 amino acids. The BD-4 is purified by proprietary chromatographic techniques
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans.

-20°C