Endoglin, human recombinant

货号： 4530-100      产品名称： Endoglin, human recombinant   品牌： Biovision 规格： 100 μg 3周到货 生化实验

Endoglin, human recombinant
A part of the TGF beta receptor complex
Product Overview
Alternate Name/Synonyms: CD105, ENG, END, ORW, HHT1, ORW1, FLJ41744, Endoglin, recombinant human Endoglin, human endoglin, recombinant endoglin
Gene Symbol: ENG
Accession #: P17813
Gene ID: 2022
Source: Sf9 cells
Appearance: Lyophilized protein
Physical Form Description: Lyophilized from PBS pH 7.4
Molecular Weight: 90.0 kDa
Purity by SDS-PAGE: ≥95%
Purity by HPLC: ≥95%
Endotoxin Level: N/A
Biological Activity: N/A
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS to a concentration ≥ 100 µg/ml. This solution can then be diluted into other aqueous buffers
Storage Temp.: -20°C
Shipping: Gel Pack
Background Information: Endoglin is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex.The protein consists of a homodimer of 180 kDA with disulfide links. It has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Endoglin has been found to be part of the TGF-beta1 receptor complex and may be involved in the binding of TGF-beta1, TGF-beta3, activin-A, BMP-2, and BMP-7. It has been postulated that endoglin is involved in the cytoskeletal organization affecting cell morphology and migration. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development . CD105 Mouse Recombinant extracellular domain produced in baculovirus is a homodimeric, glycosylated, polypeptide containing 581 amino acids and having a molecular mass of 61 kDa but as a result of glycosylation, migrates at 75-85 kDa under reducing conditions in SDS-PAGE. Based on N-terminal sequence analysis, the primary structure of recombinant mature Endoglin starts at Glu 26. The CD105 is fused to a C-terminal His-tag (6xHis) and purified by proprietary chromatographic techniques
Amino Acid Sequence: MDRGTLPLAVALLLASCSLSPTSLAETVHCDLQPVGPERGEVTYTTSQVSKGCVAQAPNAILEVHVL-FLEFPTGPSQLELTLQASKQNGTWPREVLLVLSVNSSVFLHLQALGIPLHLAYNSSLVTFQEPPGVNTTELPSFPKTQ-ILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRV-LPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGE-ARMLNASIVASFVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKC-TITGLTFWDPSCEAEDRGDKFVLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHF-LQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSL-LSPSPEGDPRFSFLLHFYTVPI PKTGTLSCTVALRPKTGS
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans.

-20°C