GDF-15-D, human recombinant

货号： 4570-1000      产品名称： GDF-15-D, human recombinant   品牌： Biovision 规格： 1 mg 3周到货 生化实验

GDF-15-D, human recombinant
A protein with functions in regulating inflammatory and apoptotic pathways
Product Overview
Product Name: GDF-15-D, human recombinant
Alternate Name/Synonyms: MIC-1, Placental TGFβ, Prostate differentiation factor
Gene Symbol: GDF-15
Accession #: Q99988
Gene ID: 9518
Source: E. coli
Appearance: Lyophilized protein
Physical Form Description: Sterile filtered and lyophilized with no additives
Molecular Weight: 26.8 kDa
Purity by SDS-PAGE: ≥95%
Purity by HPLC: N/A
Endotoxin Level: <0.01 ng/μg
Biological Activity: The activity is determined by the inhibition of DU-145 cells and is typically 1-2 µg/mL.
Reconstitution Instructions: Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile 5 mM acetic acid at a concentration of 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Storage Temp.: -20°C
Shipping: Blue ice
Background Information: Growth and differentiation factor 15 (GDF-15) is a TGFβ family member, made by in the placenta and heart tissues, that has a role in regulating inflammatory and apoptotic pathways. GDF-15 has become an immerging marker of early heart disease and has the potential as being used as a molecule for screening patients for early heart failure. Recombinant human GDF-15 (D-variant) is a non-glycosylated, disulfide linked homodimer. It is comprised of two identical 120 amino acid monomers and has a total molecular mass of 26.8 kDa. There is a His to an Asp substitution at position 7.
Amino Acid Sequence: MARNGDHCPL GPGRCCRLHT VRASLEDLGW ADWVLSPREV QVTMCIGACP SQFRAANMHA QIKTSLHRLK PDTVPAPCCV PASYNPMVLI QKTDTGVSLQ TYDDLLAKDC HCI
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans.

-20°C