Leptin Receptor, human recombinant

货号： 4582-1000      产品名称： Leptin Receptor, human recombinant   品牌： Biovision 规格： 1 mg 3周到货 生化实验

Leptin Receptor, human recombinant
A receptor for the fat cell-specific hormone leptin
Product Overview
Alternate Name/Synonyms: OB Protein, Obesity Protein, OBS, Obesity factor, HuB219, OB receptor, CD_antigen=CD295
Gene Symbol: LEP
Accession #: P41159
Gene ID: 3952
Source: Human
Appearance: Lyophilized protein
Physical Form Description: Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8 % trehalose and mannitol are added as protectants before lyophilization.
Molecular Weight: 95.0 kDa (predicted) 130-140 kDa on a gel
Purity by SDS-PAGE: ≥95%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: Biological Activity is evidenced by high affinity binding of mammalian leptins at 1:1 molar ratio
Reconstitution Instructions: Centrifuge the vial prior to opening. The lyophilized Leptin Binding Domain is very soluble in H₂O and most aqueous buffers below and above the isoelectric point (~ 5.9)
Storage Temp.: -70°C
Shipping: Blue Ice
Background Information: Leptin receptor (LEPR), also known as OB-R and B219, is a single transmembrane-domain receptor of the cytokine receptor family. Leptin receptor exists as homodimer and binds Leptin with high affinity, thus mediates the biological function of the adipocyte-specific hormone Leptin. LEPR is expressed at high levels in hematopoietic stem cells, lymphohematopoietic cell lines, as well as adult reproductive organs. Several isoforms of LEPR have been identified, and LEPR structurally contains two hemopoietin receptor domains, a fibronectin type III domain and a WSXWS domain within the extracellular region. Interaction of leptin and leptin receptor is crucial for bodyweight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure. Meanwhile, research data supports a leptin receptor activation model based on ligand-induced conformational changes.
Amino Acid Sequence: A DNA sequence encoding the extracellular domain (Met 1 – Asp 839) of human leptin receptor (NP_002294.2) was expressed and fused with a C-terminal polyhistidine tag. Predicted NT sequence is Phe 22.
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans.

-20°C