VEGF-B, human recombinant

货号： 4642-20      产品名称： VEGF-B, human recombinant   品牌： Biovision 规格： 20 μg 3周到货 生化实验

VEGF-B, human recombinant
Involved in maintenance of newly formed blood vessels during pathological conditions
Product Overview
Alternate Names / Synonyms: VEGF-B, VEGFB, VEGF B
Gene Symbol: VEGFB
Accession #: P49765
Gene ID: 7423
Source: E. coli
Appearance: Lyophilized protein
Physical Form Description: Lyophilized without additives
Molecular Weight: 19.63 kDa
Purity by SDS-PAGE: ≥98%
Purity by HPLC: N/A
Endotoxin Level: <0.1 ng/μg
Biological Activity: Per researcher’s feedback, the protein is biologically active as determined by the dose-dependent stimulation of the proliferation of human μmbilical vein endothelial cells (HUVEC) in the presence of human VEGF165. The expected ED₅₀ for this effect is 0.5-5.0 μg/ml.
Reconstitution Instructions: Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/ml. The solution should be stored at -70°C.
Storage Temp.: -20°C
Shipping: Gel pack
Background Information: VEGF-B, a member of the VEGF family, is a potent growth and angiogenic cytokine. It promotes DNA synthesis in endothelial cells, regulates angiogenesis and Vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. VEGF-B is expressed in all tissues except the liver. It forms cell surfaced-associated disulfide linked homodimers and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a “cysteine knot” like structural motif, but differ in their carboxyl-terminal domains. Both VEGF-B isoforms signal only through the VEGFR1 receptor. Recombinant human VEGF-B is a 38.0 kDa disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains.
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans.

-20°C