Chk2 Inhibitor, PV1019

货号： 220488-10MG      产品名称： Chk2 Inhibitor, PV1019   品牌： Merck 规格： *** 3周到货 生化实验

Chk2 Inhibitor, PV1019
A cell-permeable nitroindolo-guanidinohydrazone compound that acts as a potent, ATP-competitive, and highly selective Chk2 inhibitor (IC50 = 138 and 570 nM against the phosphorylation of histone H1 by Chk2 in the presence of 10 µM and 1 mM of ATP, respectively), while exhibiting much reduced or no activity against a panel of 52 other cellular kinases, including Chk1 (IC50 = 15.73 and 55 µM against substrate phosphorylation and Chk1 autophosphorylation with 10 µM ATP). Shown to effectively suppress radiation-induced phosphorylation of Chk2 (on Ser516) and its downstream substrate Cdc25c (on Ser216) in MCF7 cultures (IC50 <10 µM) and reduce the sensitivity of wild-type murine thymocytes to radiation-induced apoptosis to the level seen in Chk2-/- cultures.
产品信息
Form  Orange solid
Molar mass  379.4
Protect from Light  是的
Hygrocopic  是的
Packaged under inert gas  是的
Purity  ≥95% by HPLC
Solubility  DMSO or H2O
Chemical formula  C18H17N7O3
商店和运输信息
Storage  -20°C
Ship  Ambient Temperature Only
Standard Handling

-20°C