MDM2 E3 Ligase Inhibitor III, MEL23
货号: 373227-10MG 产品名称: MDM2 E3 Ligase Inhibitor III, MEL23 品牌: Merck 规格: *** 3周到货 生化实验
MDM2 Inhibitor VII, MEL23
A cell-permeable tetrahydro-β-carbolinylbarbiturate compound that selectively inhibits the E3 ligase activity of Mdm2-MdmX hetero-complex over that of Mdm2-Mdm2 homo-complex (70.6% vs. 17.6% inhibition, respectively, at 100 µM), without affecting Mdm2-MdmX complex formation or the activity of two other UbcH5C-utilizing ligase complexes Roc1-Cul1 and BRCA1-BARD1. Effectively inhibits ubiquitination and proteasomal degradation of cellular Mdm2 and p53 (effective conc. = 14 µM in U2OS, RKO, and HCT116 cultures) and induce RKO and MEF cell death in a p53- and Mdm2-dependent manner. Unlike Nutlin-3 (Cat. Nos. 444143 & 444151), MEL23 does not interfere with Mdm2-p53 interaction.
产品信息
Form Yellow solid
Molar mass 354.4
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C19H22N4O3
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling
2°C – 8°C
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