anti-PDGFRb, rb mono
货号： 04-397 产品名称： anti-PDGFRb, rb mono 品牌： Millipore 规格： EA 3周到货 生化实验
Anti-PDGF Receptor Beta (C-term), clone Y92, Rabbit Monoclonal
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Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB, ICC, IP, IH(P) Rabbit Unpurified Monoclonal Antibody
Description:
Anti-PDGF Receptor Beta (CT) Antibody, clone Y92, rabbit monoclonal
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Specificity:
This antibody recognizes the C-terminus of PDGF Receptor Beta. The antibody does not cross-react with other CSF-1/PDGF receptor family members.
Molecular Weight:
~190 kDa observed
Epitope:
C-terminus
Immunogen:
Synthetic peptide corresponding to the C-terminus of human PDGF Receptor Beta.
Clone:
Y92
Isotype:
IgG
Background Information:
Human platelet-derived growth factor (PDGF) receptor, is a receptor tyrosine kinase whose activity induces various signalling cascades leading to cell growth and proliferation. Two major isoforms exist, PDGF receptor-Alpha and PDGF receptor-Beta. PDGF receptor-Beta can only bind two specific PDGF isoforms, PDGF-Beta and PDGFDelta (1,2). Upon ligand binding, the receptor undergoes autophosphorylation, allowing binding and activation of cytoplasmic SH2 domain-containing signal transduction molecules such as PI kinase (3), Grb2, and Src, among others.
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Species Reactivity:
Human
Mouse
Rat
Species Reactivity Note:
Demonstrated to react with Human, Mouse and Rat.
Application Notes:
Immunohistochemistry Analysis: A 1:100 dilution from a representative lot was used in prostate carcinoma tissue.
Immunocytochemistry Analysis: A 1:100 dilution from a representative lot was used in IC.
Immunoprecipitation Analysis: A 1:30 dilution from a representative lot was used in IP.
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Control:
NIH/3T3 cell lysate
Quality Assurance:
Evaluated by Western Blot in NIH/3T3 cell lysate
WesternBlot Analysis: A 1:10,000 dilution of this antibody detected PDGF Receptor Beta in NIH/3T3 cell lysate.
Purification Method:
Unpurified
Presentation:
Rabbit Monoclonal in buffer containing glycerol, BSA, and sodium azide.
Storage Conditions:
Stable for 1 year at -20ºC from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20ºC. Avoid freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
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UniProt Number:
P09619
Entrez Gene Number:
P09619
Gene Symbol:
JTK12
PDGFR1
EC 2.7.10.1
PDGFR
CD140b
CD140B
OTTHUMP00000160528
EC 2.7.10
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Alternate Names:
platelet-derived growth factor receptor, beta polypeptide
CD140 antigen-like family member B
beta-type platelet-derived growth factor receptor
PDGF-R-beta
CD140b antigen
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption -20°C
