PGE2 ELISA kit

货号： ADI-900-001      产品名称： PGE2 ELISA kit   品牌： Enzo 规格： 1 x 96 wells 3周到货 生化实验

PGE2 ELISA kit
Highly sensitive PGE2 ELISA kit for inflammation and eicosanoid research 
Alternative size available: ADI-901-001 (5×96 wells)
•Trusted – highly cited in peer reviewed literature
•Sensitive – measure as little as 13.4 pg/ml PGE2
•Easy-to-use – ready-to-use liquid color-coded reagents reduce errors
•Higher throughput – assay up to 37 samples in duplicate in less than 3 hours
•Reliable – reproducible results day-after-day and lot-after-lot
Product Specification
Alternative Name: Prostaglandin E2
Sensitivity: 13.4 pg/ml (range 39.1 – 2,500 pg/ml)  
Assay Time: <3 hours 
Application: For the quantitative determination of PGE2 in culture supernatants, serum, saliva, urine, and whole blood from any species. Cited sample types include cell lysate (ref. 1), cerebral spinal fluid (ref. 2), dialysate (ref. 3), gingival crevicular fluid (ref. 4), peritoneal exudate fluid and peritoneal exudate cell supernatant (ref. 5), plasma (ref. 6), and tissue (ref. 7). 
Use/Stability: Store all components at 4°, except standard and conjugate at -20°. 
Kit/Set Contains: GxM IgG Microtiter plate, Conjugate, Antibody, Assay buffer, Wash buffer concentrate, Standard, pNpp Substrate, Stop solution 
Miscellaneous/General: Prostaglandin E2 (PGE2) is an extensively studied prostaglandin owing to its predominance in inflammation, cancer, atherosclerosis, autoimmune disease, and sepsis. Oxidation of arachidonic acid by prostaglandin synthases (COX-1 and COX-2) produces prostaglandin H2 (PGH2), which is further metabolized by PGE synthases into its major product, PGE2. PGE2 mediates autocrine and paracrine signaling by binding to G-protein coupled receptors (EP1, EP2, EP3, EP4) on the cell surface, functioning to modulate phospholipase C and adenylate cyclase activity. PGE2 has been of great interest as a therapeutic target, either by modulation of its synthesis by COX inhibitors (NSAIDS) or by modulation of its receptors by downregulation or binding antagonists. PGE2 production in a variety of tissues has been shown to modulate numerous physiological processes including natriuresis in the kidney, smooth muscle elasticity in the vasculature, and the inflammatory response to damaged tissues by monocytes and macrophages.

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