Leptomycin B

货号： 1814-025      产品名称： Leptomycin B   品牌： Biovision 规格： 25 μg 3周到货 生化实验

Leptomycin B
An inhibitor of nuclear export
Product Overview
Product Name: Leptomycin B
Alternate Name/Synonyms: LMB; Elactocin; Mantuamycin; CI-940; CL-1957A; PD-114720; ATS 1287B
Description: A potent, specific inhibitor of nuclear export signal (NES)-dependent protein export from the nucleus. It alkylates and inhibits CRM1 (chromosomal region maintenance)/exportin 1(XPO1), a protein required for nuclear export of proteins containing a nuclear export sequence . At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it stabilizes the expression of p53.
Peptide Sequence: N/A
Appearance: Liquid
Formulation: 0.2 mg/ml (EtOH)
CAS Number: 87081-35-4
Molecular Formula: C₃₃H₄₈O₆
Molecular Weight: 540.73
Purity: ≥99% by HPLC
Solubility:N/A
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: CCC(=CC(C)CC=CC(=CC(C)C(=O)C(C)C(C(C)CC(=CC(=O)O)C)O)C)C=CC1C(C=CC(=O)O1)C
InChi: InChI=1S/C33H48O6/c1-9-28(14-15-29-24(5)13-16-31(36)39-29)19-22(3)12-10-11-21(2)17-25(6)32(37)27(8)33(38)26(7)18-23(4)20-30(34)35/h10-11,13-17,19-20,22,24-27,29,33,38H,9,12,18H2,1-8H3,(H,34,35)/b11-10+,15-14+,21-17+,23-20+,28-19-/t22-,24+,25-,26+,27-,29+,33-/m1/s1
InChi Key: YACHGFWEQXFSBS-XYERBDPFSA-N
PubChem CID: 6917907
MDL Number: MFCD06795848
USAGE: For Research Use Only! Not For Use in Humans.

-20°C